C(sp2)-H Trifluoromethylation of enamides using TMSCF3: access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles
C(sp2)-H Trifluoromethylation of enamides using TMSCF3: access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles
复制标题
DOI：
10.1039/c8cc04907f
复制
发表时间：
2018-09-25
影响因子：
4.9
通讯作者：
Surya Prakash, G. K.
中科院分区：
文献类型：
--
作者：
Krishnamurti, Vinayak;Munoz, Socrates B.;Surya Prakash, G. K.
提出了一种在氧化条件下使用TMSCF3直接进行C(sp(2))-H三氟甲基化的方法，包括生物相关的异吲哚酮、异喹啉酮和2-吡啶酮。该协议方便，操作简单，并且在众多相关句柄和功能组之间表现出高容忍度。
A method for the direct C(sp(2))-H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.