Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice
Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice
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DOI：
10.1016/j.fitote.2015.06.002
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发表时间：
2015-09-01
期刊：
影响因子：
3.4
通讯作者：
Wu, Xiao-Hui
中科院分区：
文献类型：
--
作者：
Hou, Pi-Yong;Mi, Chao;Wu, Xiao-Hui
Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol's effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P < 0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions. (C) 2015 Published by Elsevier B.V.
