Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center
Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center
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DOI：
10.1177/0961203317751856
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发表时间：
2018-05-01
期刊：
影响因子：
2.6
通讯作者：
El Hadidi, T. S.
中科院分区：
文献类型：
--
作者：
El Hadidi, K. T.;Medhat, B. M.;El Hadidi, T. S.
前言：系统性红斑狼疮(SLE)是一种多系统自身免疫性疾病，在不同民族和种族之间存在差异。目的：本论文的目的是研究系统性红斑狼疮在埃及人群中不同表现的患病率。患者和方法：本研究中的信息来源于1980年1月至2016年6月在开罗一家私人诊所寻求医疗咨询的SLE患者的医疗记录。结果：1109例SLE患者中，男性114例(10.3%)，女性995例(89.7%)。平均发病年龄为25.89+/-10.81岁，而从发病到最后一次就诊的病程中位数为26个月。最常见的累积表现为关节炎(76.7%)、颧部皮疹(48.5%)、白细胞减少(45.7%)和光敏(45.6%)。33.1%的患者患有肾炎，6.4%的患者出现神经精神性狼疮。继发性抗磷脂综合征发生率为11.5%。抗核抗体阳性率为96.9%(1060/1094)，抗双链脱氧核糖核酸阳性率为79.3%(842/1062)。抗磷脂抗体阳性266/636(41.8%)，抗Smith抗体阳性54/240(22.5%)，抗SSA/Ro抗体61/229(20.4%)，抗SSB/La抗体32/277(11.6%)。男性肾炎的患病率高于女性(P=0.012)，而女性关节炎和脱发的患病率高于女性(P=0.006)。青少年起病患者的肾炎和癫痫发生率在统计学上更高(p
Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can vary among different ethnic and racial groups. Objective: The objective of this paper is to study the prevalence of various manifestations of SLE in a sample of the Egyptian population. Patients and methods: Information in this study was derived from the medical records of SLE patients who sought medical advice at a private clinic in Cairo from January 1980 to June 2016. Results: This study included 1109 SLE patients, of whom 114 (10.3%) were males and 995 were females (89.7%). Mean age of onset was 25.89 +/- 10.81 years, while the median of disease duration from the onset of the disease till the last recorded visit was 26 months. The most common cumulative manifestations were arthritis (76.7%), malar rash (48.5%), leukopenia (45.7%), and photosensitivity (45.6%). A total of 33.1% of the patients had nephritis, and neuropsychiatric lupus was present in 6.4% of the patients. Secondary antiphospholipid syndrome was present in 11.5% of the patients. Antinuclear antibody and anti-double-stranded deoxyribonucleic acid were present in 1060/1094 (96.9%) and 842/1062 (79.3%) of the patients, respectively. Antiphospholipid antibodies were present in 266/636 (41.8%) of the patients, anti-Smith in 54/240 (22.5%), anti-SSA/Ro in 61/229 (20.4%), and anti-SSB/La in 32/277 (11.6%) of the patients. Male patients had a statistically higher prevalence of nephritis (p=0.01), whereas arthritis and alopecia were statistically higher in females (p=0.012 and p=0.006, respectively). Patients with juvenile onset had a statistically higher prevalence of nephritis and seizures (p