Plasma growth hormone response to oral l-dopa in infantile autism.
Plasma growth hormone response to oral l-dopa in infantile autism.
复制标题
婴儿自闭症患者血浆生长激素对口服左旋多巴的反应。
DOI：
10.1007/bf01531606
复制
发表时间：
1985
影响因子：
3.9
通讯作者：
David,R
中科院分区：
文献类型：
--
作者：
Deutsch,SI;Campbell,M;Sachar,EJ;Green,WH;David,R
In order to assess further the occurrence of hypothalamic dysfunction in infantile autism and its possible relationship to dopaminergic abnormalities, the 1-dopa provocative test was performed in 22 patients fulfilling DSM-III criteria for this disorder. The results indicate a high incidence (at least 30%) of blunted plasma growth hormone (GH) responses following oral administration of 1-dopa in this sample. These data suggest an alteration of hypothalamic dopamine receptor sensitivity in the patients with blunted responses. Thus, a subgroup of autistic patients within a descriptively homogeneous diagnostic category shows evidence of hypothalamic dysregulation and dopaminergic abnormalities.
