The Potential for Circulating Tumor Cells in Pancreatic Cancer Management.
The Potential for Circulating Tumor Cells in Pancreatic Cancer Management.
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DOI：
10.3389/fphys.2017.00381
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发表时间：
2017
影响因子：
4
通讯作者：
Pandol S
中科院分区：
文献类型：
--
作者：
Pimienta M;Edderkaoui M;Wang R;Pandol S
胰腺癌是最致命的恶性肿瘤之一。只有一小部分患者能从手术中获益。化疗只能提供短暂的益处。尽管在寻找早期诊断和治疗的新方法方面已经付出了很多努力，但平均患者的生存时间只提高了几个月。循环肿瘤细胞（ctc）从原发肿瘤中脱落，包括恶性前期。这些细胞具有原位肿瘤源的基因组特征信息，它们的检测和表征在早期癌症诊断、预后和治疗中具有潜力。液体活检是肿瘤活检难以取样的一种替代方法。下面我们总结了目前CTC的检测方法，目前关于胰腺癌CTC的文献，以及未来的展望。
Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit. Though much effort has gone into finding new ways for early diagnosis and treatment, average patient survival has only been improved in the order of months. Circulating tumor cells (CTCs) are shed from primary tumors, including pre-malignant phases. These cells possess information about the genomic characteristics of their tumor source in situ, and their detection and characterization holds potential in early cancer diagnosis, prognosis, and treatment. Liquid Biopsies present an alternative to tumor biopsy that are hard to sample. Below we summarize current methods of CTC detection, the current literature on CTCs in pancreatic cancer, and future perspectives.