Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma
Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma
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DOI：
10.1158/1078-0432.ccr-03-0354
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发表时间：
2004-03-01
影响因子：
11.5
通讯作者：
Haffty, BG
中科院分区：
文献类型：
--
作者：
Chang, BW;Kim, DH;Haffty, BG
目的：确定环氧化酶（考克斯）-2表达在口咽鳞状细胞癌（SCC）患者中的相对预后意义。这项回顾性队列研究纳入了82名转诊至耶鲁-纽黑文医院放射治疗科的SCC患者（康涅狄格州），1980年至1999年之间，谁是治疗与初级外照射放疗或总的全手术切除和术后放疗。构建存档肿瘤组织的微阵列，并用针对考克斯-2的单克隆抗体染色，并由对患者临床结果不知情的病理学家对强度进行评分。考克斯-2免疫反应性和临床病理资料进行了分析，就生存终点使用双变量和多变量techniques.Results：考克斯-2过表达的频率为45%。在多变量分析中，考克斯-2阳性预测3年生存率较差（P = 0.02;比值比= 0.41; 95%可信区间，0.20-0.84）。年龄的增加与3年生存率的增加显著相关（P = 0.03;比值比= 1.04; 95%置信区间，1.004-1.09）。阳性考克斯-2状态倾向于预测3年无病生存率降低。结论：考克斯-2是该患者队列中生存率差的最重要预测因子。在口咽部鳞状细胞癌患者接受外照射治疗时，考克斯-2的过度表达可能影响临床结果，因此考克斯-2可能被证明是一个有价值的预后因素和治疗靶点。
Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous cell carcinoma (SCC).Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external beam radiotherapy or gross total surgical resection and postoperative radiotherapy. A microarray of archival tumor tissue was constructed and stained with monoclonal antibodies directed against COX-2 and scored for intensity by a pathologist blinded to the clinical outcomes of the patients. COX-2 immunoreactivity and clinicopathological data were analyzed with respect to survival endpoints using bivariate and multivariate techniques.Results: Frequency of COX-2 overexpression was 45%. In multivariate analysis, COX-2 positivity predicted poor 3-year survival (P = 0.02; odds ratio = 0.41; 95% confidence interval, 0.20-0.84). Increasing age was significantly associated with increased 3-year survival (P = 0.03; odds ratio = 1.04; 95% confidence interval, 1.004-1.09). Positive COX-2 status trended toward predicting decreased 3-year disease-free survival.Conclusions: COX-2 was the most important predictor of poor survival in this patient cohort. In patients with oropharyngeal SCC treated with external-beam radiation therapy, overexpression of COX-2 may affect clinical outcome, and COX-2 may therefore prove valuable both as a prognostic factor and as a therapeutic target.