Neural activities for negative priming with affective stimuli: An fMRI study
Neural activities for negative priming with affective stimuli: An fMRI study
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DOI：
10.1016/j.neulet.2008.01.011
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发表时间：
2008-03-15
影响因子：
2.5
通讯作者：
Li, Leonard S. W.
中科院分区：
文献类型：
--
作者：
Leung, Kwok-Keung;Lee, Tatia M. C.;Li, Leonard S. W.
负启动是指对刺激的反应时间减慢，该刺激与在之前的试验中被人们忽略的分散刺激相同或相关。它可以作为一个指标来检查人们能够在多大程度上分散注意力，甚至忽略分散注意力的刺激。在这项功能磁共振成像研究中，我们针对健康的讲普通话的中国参与者，用情感中性的词语复制了基本的负面启动效应。负启动与前扣带皮层和岛叶的活动增加有关，这一结果支持了负启动的抑制作用。我们观察到，相对于中性词语，负面情感词语会减弱负面启动效应，这表明受试者对负面信息的抑制受到了损害。负面情感词语对负面启动的这种减弱与腹外侧和内侧额叶区域、海马体和辅助运动区的活动增加有关。这些观察结果表明，特定的额叶和皮层下区域参与了对负面情绪信息的注意力定向。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Negative priming refers to the slowing down in reaction time to a stimulus that is either the same as, or related to, a distracting stimulus that has been ignored by people in an immediately preceding trial. It can be used as an index to examine the extent to which people are able to disengage attention or even ignore a distracting stimulus. In this fMRI study, with healthy Mandarin-speaking Chinese participants, we replicated the basic negative priming effect with affectively neutral words. Negative priming was associated with increased activities in the anterior cingulate cortex and the insula, a result that supports the inhibition account of negative priming. We observed that the negative priming effect was attenuated by negative affective words, relative to neutral words, suggesting that subjects' inhibition of negative information was compromised. Such attenuation of negative priming by negative affective words was associated with increased activities in the ventrolateral and medial frontal regions, the hippocampus, and supplementary motor areas. These observations indicate that specific frontal and subcortical regions take part in attention orientation toward negative- affect information. (C) 2008 Elsevier Ireland Ltd. All rights reserved.