The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh?et’s disease: A nationwide survey
The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh?et’s disease: A nationwide survey
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HLA-B51 对日本白塞氏病患者临床表现的影响：一项全国性调查
DOI：
10.1080/14397595.2019.1649103
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发表时间：
2019
影响因子：
2.2
通讯作者：
Mizuki N.
中科院分区：
文献类型：
--
作者：
Mizuki Y;Horita N;Horie Y;Takeuchi M;Ishido T;Mizuki R;Kawagoe T;Shibuya E;Yuda K;Ishido M;Minegishi K;Yoshimi R;Kirino Y;Kato S;Arimoto J;Fukumoto T;Kurosawa M;Kitaichi N;Takeno M;Kaneko T;Mizuki N.
目的：利用日本厚生劳动省数据库，研究白塞病（BD）患者HLA-B51对BD临床表现的影响。符合白塞病国际标准（ICBD）和HLA-B51. Results数据的患者进行了选择和分析：在3044例可分析的情况下，1334（43.8%）是男性和1710（56.2%）是女性，中位年龄为38岁（IQR 29-48）。HLA-B51阳性1334例（44.5%）。口腔溃疡、皮肤损害、眼部损害、生殖器溃疡和胃肠道症状的检出率分别为98.5%、85.5%、42.1%、69.1%和29.0%。HLA-B51阳性患者眼部病变风险较高（OR 1.59，95%CI：1.37-1.84;p< .001），生殖器溃疡风险较低（OR 0.72，95%CI：0.62-0.84;p< .001），胃肠道症状风险较低（OR 0.65，95%CI：0.55-0.77;p< .001）。在其他器官受累方面没有观察到显著差异;口腔溃疡、皮肤病变、病理学试验阳性、关节炎、附睾炎、血管病变或神经系统表现。亚组分析显示，HLA-B51是不相关的ICBD评分为6或更高的情况下，生殖器溃疡和HLA-B51往往更大程度上影响的风险，男性的三种表现相比，为women.Conclusion：HLA-B51阳性是一个危险因素，眼部病变，反之亦然，生殖器溃疡和消化道症状的患者与日本BD。
Objectives:To scrutinize the influence of HLA-B51 to each clinical manifestation of patients with Behçet’s disease (BD) using a database of the Ministry of Health, Labour and Welfare of Japan.Methods:The database of newly registered patients with BD was obtained from the Japanese Ministry of Health, Labour and Welfare. Patients who met International Criteria for Behçet's Disease (ICBD) and had data for HLA-B51 were selected and analyzed.Results:Among the 3044 analyzable cases, 1334 (43.8%) were men and 1710 (56.2%) were women; the median age was 38 years (IQR 29–48). HLA-B51 was positive for 1334 (44.5%). Prevalence of selected manifestations was 98.5% for oral ulceration, 85.5% for skin lesion, 42.1% for ocular lesion, 69.1% for genital ulceration, and 29.0% for gastrointestinal symptom. HLA-B51-positive patients had higher risk for ocular lesion (OR 1.59, 95%CI: 1.37–1.84;p< .001) and lower risk for genital ulceration (OR 0.72, 95%CI: 0.62–0.84;p< .001) and gastrointestinal symptom (OR 0.65, 95%CI: 0.55–0.77;p< .001). No significant difference was observed for other organ involvement; oral ulceration, skin lesion, positive pathergy test, arthritis, epididymitis, vascular lesion, or neurological manifestation. Subgroup analyses revealed that HLA-B51 was not related to genital ulceration in the cases with an ICBD score of 6 or higher and that HLA-B51 tended to more largely affect the risk of three manifestations for men compared to that for women.Conclusion:HLA-B51 positive is a risk factor for ocular lesion and vice versa for genital ulceration and gastrointestinal symptoms in patients with Japanese BD.