Leisure activities and the risk of amnestic mild cognitive impairment in the elderly
Leisure activities and the risk of amnestic mild cognitive impairment in the elderly
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DOI：
10.1212/01.wnl.0000202520.68987.48
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发表时间：
2006-03-28
期刊：
影响因子：
9.9
通讯作者：
Lipton, RB
中科院分区：
文献类型：
--
作者：
Verghese, J;LeValley, A;Lipton, RB
目的：研究休闲活动参与对遗忘性轻度认知障碍（aMCI）发生风险的影响。方法：作者使用针对年龄、性别、教育程度和慢性病进行调整后的 Cox 分析，研究了 437 名年龄超过 75 岁、最初没有痴呆或 aMCI 的社区居民前瞻性队列中参与休闲活动的基线水平与 aMCI 风险之间的关系。作者根据参与个人活动的频率得出了认知和身体活动量表。结果：在中位随访 5.6 年中，58 名受试者出现了 aMCI。认知（风险比 [HR] 0.95，95% CI 0.91 至 0.99）增加 1 分与体力活动量表（HR 0.97，95% CI 0.93 至 1.01）无关，与 aMCI 风险降低相关。认知活动得分最高（HR 0.46，95% CI 0.24 - 0.91）和中间三分之一（HR 0.52，95% CI 0.29 - 0.96）的受试者与最低三分之一的受试者相比，aMCI 风险较低。即使排除了在满足 aMCI 标准后 2 年内转变为痴呆的受试者，这种关联仍然存在。结论：即使排除了早期痴呆症患者，参与认知活动与发生遗忘性轻度认知障碍的风险较低相关。
Objective: To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI). Methods: The authors examined the relationship between baseline level of participation in leisure activities and risk of aMCI in a prospective cohort of 437 community-residing subjects older than 75 years, initially free of dementia or aMCI, using Cox analysis adjusted for age, sex, education, and chronic illnesses. The authors derived Cognitive and Physical Activity Scales based on frequency of participation in individual activities. Results: Over a median follow-up of 5.6 years, 58 subjects had development of aMCI. A one-point increase on the Cognitive (hazard ratio [HR] 0.95, 95% CI 0.91 to 0.99) but not Physical Activities Scale (HR 0.97, 95% CI 0.93 to 1.01) was associated with lower risk of aMCI. Subjects with Cognitive Activity scores in the highest (HR 0.46, 95% CI 0.24 to 0.91) and middle thirds (HR 0.52, 95% CI 0.29 to 0.96) had a lower risk of aMCI compared with subjects in the lowest third. The association persisted even after excluding subjects who converted to dementia within 2 years of meeting criteria for aMCI. Conclusions: Cognitive activity participation is associated with lower risk of development of amnestic mild cognitive impairment, even after excluding individuals at early stages of dementia.