ROLES OF THE NOTCH GENE IN DROSOPHILA WING MORPHOGENESIS
ROLES OF THE NOTCH GENE IN DROSOPHILA WING MORPHOGENESIS
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DOI：
10.1016/0925-4773(94)90080-9
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发表时间：
1994-05-01
影响因子：
2.6
通讯作者：
GARCIABELLIDO, A
中科院分区：
文献类型：
--
作者：
DECELIS, JF;GARCIABELLIDO, A
Notch基因编码一种跨膜蛋白，在果蝇的许多发育过程中起细胞间信号受体的作用。我们在此研究了Notch在翅膀形态发生中的功能，以及Notch无和Notch功能获得等位基因的遗传嵌合体中的静脉模式。突变型Notch细胞的细胞增殖和分化特性决定了三种不同的Notch需求：在视像盘细胞增殖中，在静脉分化的限制中，在边缘形成中。对不同突变背景下Notch嵌合体的研究表明，在表皮细胞增殖和翼静脉分化过程中，Notch的活性是通过调控一组共同的基因来发挥的，这些基因参与了静脉主管区的规范和限制。
The Notch gene encodes a transmembrane protein that functions as a receptor of intercellular signals in many developmental processes of Drosophila. We study here the Notch function in wing morphogenesis and vein patterning in genetic mosaics of both Notch null and Notch gain-of-function alleles. Cell proliferation and differentiation properties of mutant Notch cells define three different Notch requirements in the wing: in imaginal disc cell proliferation, in restriction of vein differentiation and in margin formation. The study of Notch mosaics in different mutant backgrounds reveals that Notch activity during epidermal cell proliferation and wing vein differentiation is exerted by its regulation of a common group of genes involved in the specification and restriction of vein competent regions.