Zinc-altered immune function
Zinc-altered immune function
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DOI：
10.1093/jn/133.5.1452s
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发表时间：
2003-05-01
影响因子：
4.2
通讯作者：
Rink, L
中科院分区：
文献类型：
--
作者：
Ibs, KH;Rink, L
众所周知，锌对人体中所有高度增殖的细胞，尤其是免疫系统，都是必不可少的。锌对免疫细胞的多种体内外作用主要取决于锌的浓度。锌缺乏后，各种免疫细胞功能均下降。在单核细胞中，所有功能都受损，而在自然杀伤细胞中，细胞毒性降低，在中性粒细胞中，吞噬作用减少。T细胞的正常功能受损，但自身反应性和异体反应性增强。B细胞凋亡。锌缺乏导致的免疫功能受损可以通过补充足够的锌来逆转，但补充锌必须适应患者的实际需求。高剂量的锌会对免疫细胞产生负面影响，并显示出与缺锌相似的变化。此外，当外周血单核细胞与锌体外孵育时，诱导白细胞介素(IL)-1和-6、肿瘤坏死因子- α、可溶性IL- 2r和干扰素- γ等细胞因子的释放。在100 μ mol/L的浓度下，锌抑制自然杀伤细胞的杀伤和t细胞的功能，而单核细胞。在500 μ mol/L的浓度下，锌会引起直接的趋化激活。中性粒细胞。在这个简短的概述中讨论了所有这些影响。
Zinc is known to be essential for all highly proliferating cells in the human body, especially the immune system. A variety of in vivo and in vitro effects of zinc on immune cells mainly depend on the zinc concentration. All kinds of immune cells show decreased function after zinc depletion. In monocytes, all functions are impaired, whereas in natural killer cells, cytotoxicity is decreased, and in neutrophil granulocytes, phagocytosis is reduced. The normal functions of T cells are impaired, but autoreactivity and alloreactivity are increased. B cells undergo apoptosis. Impaired immune functions due to zinc deficiency are shown to be reversed by an adequate zinc supplementation, which must be adapted to the actual requirements of the patient. High dosages of zinc evoke negative effects on immune cells and show alterations that are similar to those observed with zinc deficiency. Furthermore, when peripheral blood mononuclear cells are incubated With zinc in vitro, the release of cytokines such as interleukins (IL)-1 and -6, tumor necrosis factor-alpha, soluble IL-2R and interferon-gamma is induced. In a concentration of 100 mumol/L, zinc suppresses natural killer cell killing and T-cell functions whereas monocytes. are activated directly, and in a concentration of 500 mumol/L, zinc evokes a direct chemotactic activation. of neutrophil granulocytes. All of these effects are discussed in this short overview.