Human somatosensory area 2: Observer-independent cytoarchitectonic mapping, interindividual variability, and population map
Human somatosensory area 2: Observer-independent cytoarchitectonic mapping, interindividual variability, and population map
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DOI：
10.1006/nimg.2001.0858
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发表时间：
2001-09-01
期刊：
影响因子：
5.7
通讯作者：
Zilles, K
中科院分区：
文献类型：
--
作者：
Grefkes, C;Geyer, S;Zilles, K
我们分析了10个死后脑的人体体感2区的地形变异。将脑在20 μ m连续切片，并对切片进行细胞体染色。基于细胞体层密度的显著差异，使用非依赖于细胞生长的技术描绘区域2。在组织学处理之前，用相同脑的MR扫描校正切片。每个大脑的组织学体积和区域2的表示随后在3-D中重建。我们发现区域2的边界在地形上是可变的。吻侧缘位于中央后回的凸面和中央后沟吻侧壁几毫米深之间。尾侧缘位于中央后沟底部和其上方几毫米的吻壁之间。与Brodmann的地图相反，区域2没有延伸到近中皮质表面或顶内沟。当中央后沟被脑回桥中断时，2区穿过这座桥，不被分成两段。在细胞结构分析之后，将组织学体积扭曲到计算机化图谱的参考脑中并叠加。在3D空间中生成了一个人口图，它描述了在特定体素中有多少大脑具有区域2的表示。这个微结构定义的人口地图可以用来证明激活区2的功能成像研究，因此有助于进一步了解区2在躯体感觉处理的作用。(C)北京：科学出版社.
We analyzed the topographical variability of human somatosensory area 2 in 10 postmortem brains. The brains were serially sectioned at 20 mum, and sections were stained for cell bodies. Area 2 was delineated with an observer-independent technique based on significant differences in the laminar densities of cell bodies. The sections were corrected with an MR scan of the same brain obtained before histological processing. Each brain's histological volume and representation of area 2 was subsequently reconstructed in 3-D. We found that the borders of area 2 are topographically variable. The rostral border lies between the convexity of the postcentral gyrus and some millimeters deep in the rostral wall of the postcentral sulcus. The caudal border lies between the fundus of the postcentral sulcus and some millimeters above it in the rostral wall. In contrast to Brodmann's map, area 2 does not extend onto the mesial cortical surface or into the intraparietal sulcus. When the postcentral sulcus is interrupted by a gyral bridge, area 2 crosses this bridge and is not separated into two segments. After cytoarchitectonic analysis, the histological volumes were warped to the reference brain of a computerized atlas and superimposed. A population map was generated in 3-D space, which describes how many brains have a representation of area 2 in a particular voxel. This microstructurally defined population map can be used to demonstrate activations of area 2 in functional imaging studies and therefore help to further understand the role of area 2 in somatosensory processing. (C) 2001 Academic Press.