MEASLES-VIRUS - A SUMMARY OF EXPERIMENTS CONCERNED WITH ISOLATION, PROPERTIES, AND BEHAVIOR
MEASLES-VIRUS - A SUMMARY OF EXPERIMENTS CONCERNED WITH ISOLATION, PROPERTIES, AND BEHAVIOR
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DOI：
10.2105/ajph.47.3.275
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发表时间：
1957-01-01
期刊：
影响因子：
--
通讯作者：
HOLLOWAY, A
中科院分区：
文献类型：
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作者：
ENDERS, JF;PEEBLES, TC;HOLLOWAY, A
总结了近3年来开展的麻疹病毒研究的结果。利用人源性细胞的组织培养技术的应用提供了从患者身上分离病毒、确定其传染性和确定其他生物学特性的手段。最近获得的数据首次以初步方式提出，表明该病毒可以在发育中的鸡胚中培养。本文所述的某些发现，为直接测定用于诱导被动免疫的人γ球蛋白或其他含有麻疹抗体的材料的效力提供了方法。通过组织培养技术证明病毒在鸡胚中繁殖，为在比过去更精确的控制条件下重新尝试开发有效疫苗提供了基础。
Results of studies of measles virus carried out during the last 3 years are summarized. Application of tissue culture techniques employing cells of human origin has provided means whereby the virus can be isolated from patients, its infectivity determined and other biologic properties defined. Data more recently obtained are presented for the first time in a preliminary manner which show that the virus can be cultivated in the developing chick embryo. Certain of these findings, described in this paper, afford procedures for the direct assay of the potency of human gamma globulin or other materials containing measles antibodies used for the induction of passive immunity. The demonstration by means of tissue culture techniques of the multiplication of the virus in chick embryos offers a basis for renewed attempts to develop an effective vaccine under conditions of more accurate control than have been available in the past.