Transcription regulator Yin-yang 1: from silence to cancer.
Transcription regulator Yin-yang 1: from silence to cancer.
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DOI：
10.1615/critrevoncog.v16.i3-4.60
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发表时间：
2011
影响因子：
--
通讯作者：
Garbán H
中科院分区：
文献类型：
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作者：
Zhu W;Olson SY;Garbán H
阴阳（YY） 1代表了被认为是“瑞士军刀”转录因子和调节因子的缩影。YY1是一种普遍存在的多功能锌指转录因子，是Polycomb蛋白家族的成员，Polycomb蛋白家族是一组同源盒基因受体，可以作为转录活性的激活剂或抑制剂。此外，YY1还可以作为氧化还原传感器、适配器分子和染色质结构和功能调节剂。YY1作为转录激活因子和抑制因子的特征功能依赖于它的C2H2 （x4）锌指结构dna结合基序与2个特定的调控结构域纠缠在一起。这种结构构象使YY1的活性容易受到细胞氧化还原状态变化的影响。YY1也被证明通过与组蛋白乙酰转移酶和组蛋白去乙酰化酶复合物的相互作用进行染色质重塑。两组都修饰组蛋白，导致染色质结构改变。在此，我们将讨论YY1在基因表达调控中的多重作用和机制，其遗传因子功能，表观遗传调控活性，以及其在恶性肿瘤疾病中作为氧化还原传感器的作用。
Yin Yang (YY) 1 represents the epitome of what is considered to be a “Swiss army knife” transcription factor and regulator. YY1 is a ubiquitous and multifunctional zinc-finger transcription factor member of the Polycomb group protein family, a group of homeobox gene receptors that can act as activators or repressors of transcriptional activity. Furthermore, YY1 can act as a redox sensor, adaptor molecule, and chromatin structure and function regulator. YY1’s characteristic function as transcriptional activator and repressor relies on its C2H2 (x4) zinc-finger structural DNA-binding motifs tangled with 2 specific regulatory domains. This structural conformation will render the activity of YY1 susceptible to changes in cellular redox status. YY1 also has been shown to undergo chromatin remodeling via interactions with histone acetyl transferase and histone deacetylase complexes. Both groups modify histones, resulting in altered chromatin structure. Herein, we will discuss the multiple roles and mechanisms of YY1 in the regulation of gene expression, its genetic factor functions, epigenetic regulatory activity, and its role as a redox sensor in the context of malignant neoplastic diseases.