AGING IN GERM-FREE MICE - LIFE TABLES AND LESIONS OBSERVED AT NATURAL DEATH
AGING IN GERM-FREE MICE - LIFE TABLES AND LESIONS OBSERVED AT NATURAL DEATH
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DOI：
10.1093/geronj/21.3.380
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发表时间：
1966-01-01
期刊：
影响因子：
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通讯作者：
WOSTMANN, BS
中科院分区：
文献类型：
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作者：
GORDON, HA;BRUCKNER.E;WOSTMANN, BS
300只无菌小鼠和相当数量的常规对照小鼠被饲养到自然死亡。无菌动物在其一生中表现出相当不发达的防御成分。与之相对应的是，正常生活中由正常微生物菌群引起的进行性炎症变化似乎对宿主明显有害。与这些变化相反，无菌动物的下肠异常（盲肠肿大，肠内容物更加液体化，肠道推进运动受损）表明，随着年龄的增长，无菌生活明显受到阻碍。在正常生活中，微生物群似乎消除了这些异常。无菌小鼠的平均年龄高于饲喂相同灭菌日粮或非无菌实用日粮的常规对照组。无菌雄鼠组的平均年龄与无菌雌鼠组相似，甚至可能更高。在常规对照中，这些情况似乎正好相反。无菌动物的肠道功能异常，与传统动物的菌群引起的病变相比，代表了微生物状态的根本不同的后果。由此产生的不同类型的伤害似乎是导致两种对立动物类别死亡的主要因素（如果不是主要因素）。
Three hundred germ-free and a comparable number of conventional control mice were held until natural death. Germ-free animals displayed considerable underdevelopment of defensive elements throughout life. A counterpart of these, the progressive inflammatory changes imparted by the normal microbial flora in normal life, seemed clearly detrimental to the host. Contrary to these changes, anomalies in the lower bowel of germ-free animals (cecal enlargement, more liquid intestinal contents, impairment of propulsive movements of the gut) indicated a distinct handicap of germ-free life that progresses with age. In normal life the microbial flora seems to eliminate these anomalies. Germ-free mice showed higher mean age than conventional controls fed the same sterilized ration or non-sterile practical ration. Mean age in groups of germ-free male mice was similar or indicated possibly even higher values than in germ free female groups. In conventional controls these conditions seemed reversed. The germ-free animal with its anomalous bowel function, in comparison to the conventional animal with its flora-caused lesions, represents fundamentally different consequences of microbial status. The resulting different types of injury appear to be a major factor (if not the major factor) in the cause of death of the 2 opposing animal categories.