Plasma norepinephrine in normal young and aged men: relationship with sleep.
Plasma norepinephrine in normal young and aged men: relationship with sleep.
复制标题
正常年轻和老年男性的血浆去甲肾上腺素：与睡眠的关系。
DOI：
10.1093/geronj/39.5.561
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Halter,JB
中科院分区：
文献类型：
--
作者：
Prinz,PN;Vitiello,MV;Smallwood,RG;Schoene,RB;Halter,JB
这项研究探讨了血浆去甲肾上腺素（NE）水平（被认为反映交感神经系统活动增强）与睡眠之间的关系。在24小时的研究期间，8名老年男性的血浆NE水平持续显著高于10名年轻男性。对于两组，血浆儿茶酚胺水平在就寝时间和起床时间以及自发和实验诱导的夜间觉醒期间保持稳定；睡眠/觉醒模式（夜间清醒，白天睡眠）的逆转对24小时血浆NE或睡眠模式几乎没有影响，这表明NE升高不能归因于睡眠/觉醒改变本身。在所有研究条件下，老年组在床上时明显更清醒，血浆NE水平明显更高。这两个变量显著相关，表明增强的交感神经活动可能会使老年人的睡眠与清醒分开。
This study explored the relationship between age-related elevations of plasma norepinephrine (NE) levels (thought to reflect heightened sympathetic nervous system activity) and sleep. Plasma NE levels were consistently and significantly greater in 8 aged than 10 young men across a 24-hr study period. For both groups, plasma catecholamine levels remained stable near bedtimes and rise times and during spontaneous and experimentally induced nighttime awakenings; reversal of the sleep/wake pattern (nighttime wakefulness, daytime sleep) had little effect on the 24-hr plasma NE or sleep patterns, indicating that elevated NE cannot be attributed to altered sleep/wakefulness per se. The aged group had significantly more wakefulness and significantly higher plasma NE levels while in bed in all study conditions. These two variables were significantly correlated, suggesting that heightened sympathetic activity may fragment sleep with wakefulness in the aged.