ASSESSING THE USE OF MEDICATIONS IN THE ELDERLY - METHODS AND INITIAL EXPERIENCE IN THE CARDIOVASCULAR HEALTH STUDY
ASSESSING THE USE OF MEDICATIONS IN THE ELDERLY - METHODS AND INITIAL EXPERIENCE IN THE CARDIOVASCULAR HEALTH STUDY
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DOI：
10.1016/0895-4356(92)90143-b
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发表时间：
1992-06-01
影响因子：
7.2
通讯作者：
LYLES, M
中科院分区：
文献类型：
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作者：
PSATY, BM;LEE, M;LYLES, M
心血管健康研究（CHS）是一项冠心病和中风危险因素的队列研究，招募了5201名65岁或以上的社区居民。为了评估基线时药物使用的流行程度，我们使用了药物清单的方法，并从处方瓶中转录了药物名称和剂量的信息。使用专门编写的计算机程序，不了解药物命名法的人对输入的11,846种药物中的10,511种（89%）进行了编码。我们比较了药物清单的结果和特定药物问题的答案的信度和效度。用药物清单法评估β受体阻滞剂和β受体激动剂的使用，而不是用定向回忆法评估，与平均心率的显著影响有关。在5197名有用药资料的参与者中，76.1%的人至少服用一种药物，人均药物数量为2.28种。在有高血压病史的参与者中，有心血管疾病（CVD）的参与者更有可能接受治疗，他们比没有心血管疾病的参与者更有可能服用-受体阻滞剂和钙通道阻滞剂。心血管疾病患者（30.5%的女性和43.2%的男性）比非心血管疾病患者（14.0%的女性和14.0%的男性）每天服用阿司匹林更常见。绝经后雌激素的使用在四个临床中心之间差异显著（范围= 5.5%-22.5%的妇女）。我们的结论是，这种评估药物的方法易于使用，并提供了可能影响心血管疾病风险的药物暴露的估计。
The Cardiovascular Health Study (CHS), a cohort study of risk factors for coronary heart disease and stroke, recruited 5201 community-dwelling adults aged 65 years or older. To assess the prevalence of medication use at baseline, we used the method of medication inventory and transcribed information about drug names and doses from prescription bottles. Using a specially-written computer program, persons without a knowledge of drug nomenclature coded 10,511 (89%) of the 11,846 medicines entered. We compared the results of the medication inventory and answers to questions on specific medications for reliability and validity. The use of beta-blockers and beta-agonists assessed by the method of medication inventory, but not by the method of directed recall, was associated with a significant effect on mean heart rate. Among 5197 participants with medication data, 76.1% were taking at least one medicine, and the mean number of drugs per person was 2.28. Among those with a reported history of high blood pressure, participants with cardiovascular disease (CVD) were more likely to be treated, and they were more likely to be taking beta-blockers and calcium-channel blockers than those without CVD. Daily aspirin use was also more common among those with CVD (30.5% of women and 43.2% of men) than among those without CVD (14.0% of women and 14.0% of men). The prevalence of post-menopausal estrogen use differed significantly among the four clinical centers (range = 5.5%-22.5% of women). We conclude that this method of assessing medications was easy to use and provided estimates of exposure to drugs that may affect risk of cardiovascular disease.