Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.
Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.
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DOI：
10.1002/ptr.1088
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发表时间：
2003-02-01
影响因子：
7.2
通讯作者：
Dashavantha, RV
中科院分区：
文献类型：
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作者：
Chandramu, C;Manohar, RD;Dashavantha, RV
从黄荆（Vitex negundo L.）叶中首次分离得到两个五环三萜化合物桦木酸（betullinic acid，3 β-hydroxylup-20-（29）-en-28-oic acid）（3）和熊果酸（ursolic acid，4）。沿着的还有其他三种化合物;脂肪醇正三十烷醇（1）、β-谷甾醇（2）和对羟基苯甲酸（5）。用纸片法测定了它们对农业害虫蓖麻尺蠖（Achoea janata）幼虫的拒食活性和对枯草芽孢杆菌和大肠杆菌的抗菌活性。熊果酸（4）的拒食活性强于桦木酸（3）。然而，这两种化合物都显示出非常温和的抗菌活性。其他三种化合物;正三十一烷醇（1）、β-谷甾醇（2）和对羟基苯甲酸（5）对幼虫显示出少量拒食活性，但没有显示出任何抗菌活性。版权所有（C）2003约翰威利父子有限公司。
Two pentacyclic triterpenoids, betullinic acid (3beta-hydroxylup-20-(29)-en-28-oic acid) (3), and ursolic acid (2,6-hydroxyurs-12-en-28-oic acid) (4), were isolated for the first time from leaves of Vitex negundo L. along with three other compounds; an aliphatic alcohol n-hentriacontanol (1), beta-sitosterol (2) and p-hydroxybenzoic acid (5). Their antifeedant activity against the larvae of an agricultural pest, the castor semilooper (Achoea janata), in a no-choice laboratory assay and their antibacterial activity against Bacillus subtilis and Escherichia coli, by the paper disc method, were tested. Ursolic acid (4) showed more effective antifeedant activity than the betulinic acid (3). However, both these compounds have shown a very mild antibacterial activity. The other three compounds; n-hentriacontanol (1), beta-sitosterol (2) and p-hydroxybenzoic acid (5) have shown a little antifeedant activity against the larvae and did not show any antibacterial activity. Copyright (C) 2003 John Wiley Sons, Ltd.