TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.
TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.
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DOI：
10.1016/j.cellsig.2011.06.004
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发表时间：
2011-11
影响因子：
4.8
通讯作者：
Lin FT
中科院分区：
文献类型：
--
作者：
Lin VT;Lin FT
甲状腺激素受体相互作用蛋白6(TRIP6)，又称凝集素相关蛋白-1(ZRP-1)，属于凝集素LIM蛋白家族。TRIP6主要定位于胞浆或局灶性黏附斑块，可能与肌动蛋白细胞骨架有关。此外，它还能够穿梭到细胞核中，作为转录辅助调节因子。结构和功能分析表明，通过多结构域介导的蛋白质-蛋白质相互作用，TRIP6可以作为一个平台，募集多种信号分子参与不同的细胞反应，如肌动蛋白细胞骨架重组、细胞黏附和迁移、抗凋亡信号、破骨细胞封闭区的形成和转录调控。尽管TRIP6的生理功能仍不清楚，但它与癌症进展和端粒保护有关。总之，这些研究表明，TRIP6在不同的细胞反应中发挥多功能作用，因此可能成为治疗干预的新靶点。
Thyroid hormone receptor interacting protein 6 (TRIP6), also known as zyxin-related protein-1 (ZRP-1), is an adaptor protein that belongs to the zyxin family of LIM proteins. TRIP6 is primarily localized in the cytosol or focal adhesion plaques, and may associate with the actin cytoskeleton. Additionally, it is capable of shuttling to the nucleus to serve as a transcriptional coregulator. Structural and functional analyses have revealed that through multidomain-mediated protein-protein interactions, TRIP6 serves as a platform for the recruitment of a wide variety of signaling molecules involved in diverse cellular responses, such as actin cytoskeletal reorganization, cell adhesion and migration, antiapoptotic signaling, osteoclast sealing zone formation and transcriptional control. Although the physiological functions of TRIP6 remain largely unknown, it has been implicated in cancer progression and telomere protection. Together, these studies suggest that TRIP6 plays multifunctional roles in different cellular responses, and thus may represent a novel target for therapeutic intervention.
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影响因子：
5.3
作者：
Lai, YJ;Chen, CS;Lin, FT
通讯作者：
Lin, FT
影响因子：
4.8
作者：
Lai, Yun-Ju;Lin, Weei-Chin;Lin, Fang-Tsyr
通讯作者：
Lin, Fang-Tsyr
影响因子：
64.8
作者：
KIM, E;NIETHAMMER, M;SHENG, M
通讯作者：
SHENG, M
影响因子：
9.2
作者：
Fanning, AS;Anderson, JM
通讯作者：
Anderson, JM
DOI：
10.1084/jem.20050421
发表时间：
2005-10-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Li C;Dandridge KS;Di A;Marrs KL;Harris EL;Roy K;Jackson JS;Makarova NV;Fujiwara Y;Farrar PL;Nelson DJ;Tigyi GJ;Naren AP
通讯作者：
Naren AP