PHYSIOLOGICAL-ROLE OF ALPHA-MELANOCYTE-STIMULATING HORMONE IN MODULATING THE SECRETION OF PROLACTIN AND LUTEINIZING-HORMONE IN THE FEMALE RAT
PHYSIOLOGICAL-ROLE OF ALPHA-MELANOCYTE-STIMULATING HORMONE IN MODULATING THE SECRETION OF PROLACTIN AND LUTEINIZING-HORMONE IN THE FEMALE RAT
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DOI：
10.1073/pnas.81.24.8004
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
MCCANN, SM
中科院分区：
文献类型：
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作者：
KHORRAM, O;DECASTRO, JCB;MCCANN, SM
将5μl抗α-MSH抗血清的球蛋白级分或等体积的正常兔血清(NRS)的球蛋白级分注射到长期卵巢切除(OVX)大鼠的第三脑室中。脑α-MSH的免疫中和导致催乳素(Prl)分泌曲线下面积、Prl脉冲幅度和平均血浆Prl增加(P＜0.01)。在接受 2 次 NRS 或抗 MSH 注射并经受 2 分钟乙醚应激的动物中，注射 NRS 的大鼠中的 Prl 水平在 5 分钟内显着升高，而注射抗血清的大鼠中的 Prl 水平没有从最初的高基线水平进一步升高。施用抗α-MSH抗体导致黄体生成素(LH)分泌面积和平均血浆LH小幅增加(P＜0.05)；然而，LH 脉冲的数量不受影响。中枢来源的内源性α-MSH是OVX大鼠中Prl和LH释放的生理神经调节剂，并且参与应激诱导的Prl释放。
Long-term ovariectomized (OVX) rats were injected in the 3rd cerebral ventricle with 5 .mu.l of the globulin fraction of an antiserum raised against .alpha.-MSH or an equal volume of the globulin fraction of normal rabbit serum (NRS). Immunoneutralization of brain .alpha.-MSH produced an increase in the area under the secretion curve of prolactin (Prl), the amplitude of Prl pulses, and mean plasma Prl (P < 0.01). In animals that had received 2 injections of NRS or anti-MSH and were subjected to a 2-min ether stress, Prl levels significantly increased within 5 min in the NRS-injected rats, whereas Prl levels in the antiserum-injected rats did not increase any further from the initially high baseline levels. The administration of antibodies against .alpha.-MSH produced a small increase (P < 0.05) in the area under the secretion of luteinizing hormone (LH) and mean plasma LH; however, the number of LH pulses was unaffected. Endogenous .alpha.-MSH of central origin is a physiological neuromodulator of release of Prl and LH in the OVX rat and is involved in the stress-induced release of Prl.