Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma.
Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma.
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深入了解屋尘螨介导的过敏性哮喘中的粘膜先天免疫反应。
DOI：
10.3389/fimmu.2020.534501
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发表时间：
2020
影响因子：
7.3
通讯作者：
Boyaka PN
中科院分区：
文献类型：
--
作者：
Abu Khweek A;Kim E;Joldrichsen MR;Amer AO;Boyaka PN
The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct and indirect costs. Asthma is defined as chronic heterogeneous inflammatory diseases characterized by airway obstruction, mucus production and bronchospasm. Different endotypes of asthma are being recognized based on the distinct pathophysiology, genetic predisposition, age, prognosis, and response to remedies. Mucosal innate response to environmental triggers such as pollen, cigarette smoke, fragrances, viral infection, and house dust mite (HDM) are now recognized to play an important role in allergic asthma. HDM are the most pervasive allergens that co-habitat with us, as they are ubiquitous in-house dusts, mattress and bedsheets, and feed on a diet of exfoliated human skin flakes. Dermatophagoides pteronyssinus, is one among several HDM identified up to date. During the last decade, extensive studies have been fundamental in elucidating the interactions between HDM allergens, the host immune systems and airways. Moreover, the paradigm in the field of HDM-mediated allergy has been shifted away from being solely a Th2-geared to a complex response orchestrated via extensive crosstalk between the epithelium, professional antigen presenting cells (APCs) and components of the adaptive immunity. In fact, HDM have several lessons to teach us about their allergenicity, the complex interactions that stimulate innate immunity in initiating and perpetuating the lung inflammation. Herein, we review main allergens of Dermatophagoides pteronyssinus and their interactions with immunological sentinels that promote allergic sensitization and activation of innate immunity, which is critical for the development of the Th2 biased adaptive immunity to HDM allergens and development of allergic asthma.
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DOI：
10.1084/jem.20100793
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barrett NA;Rahman OM;Fernandez JM;Parsons MW;Xing W;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
影响因子：
14.2
作者：
Chan, Tze Khee;Loh, Xin Yi;Engelward, Bevin P.
通讯作者：
Engelward, Bevin P.
DOI：
10.1165/rcmb.2003-0060oc
发表时间：
2003-09-01
影响因子：
6.4
作者：
Brown, A;Farmer, K;Sallenave, JM
通讯作者：
Sallenave, JM
影响因子：
4.8
作者：
Adam, E;Hansen, KK;Jacquet, A
通讯作者：
Jacquet, A
影响因子：
4.4
作者：
Asokananthan, N;Graham, PT;Stewart, GA
通讯作者：
Stewart, GA