Transfer RNA gene recruitment in mitochondrial DNA
Transfer RNA gene recruitment in mitochondrial DNA
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DOI：
10.1016/j.tig.2005.01.004
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发表时间：
2005-03-01
影响因子：
11.4
通讯作者：
Lang, BF
中科院分区：
文献类型：
--
作者：
Lavrov, DV;Lang, BF
转移RNA(Transfer RNA，tRNA)是一种适配分子，它介导对mRNA中密码子序列的识别，并使其翻译成适当的氨基酸。因此，tRNA基因之间的系统发育关系通常被认为概括了遗传密码的进化。然而，实验证明，一个tRNA基因可以被另一个基因的拷贝取代，另一个基因的反密码子序列带有单一突变。在这篇文章中，我们发现这种“基因募集”最近在波纹夜蛾的线粒体基因组中反复发生，似乎是tRNA多基因家族进化过程中的一种普遍现象。
Transfer RNA (tRNA) is the adaptor molecule that mediates recognition of the codon sequence in mRNA and enables its translation into the appropriate amino acid. Accordingly, phylogenetic relationships among tRNA genes are often thought to recapitulate the evolution of the genetic code. However, it has been demonstrated experimentally that one tRNA gene can be replaced with a copy of another carrying a single mutation in its anticodon sequence. In this article, we show that such 'gene recruitment' has occurred recently and repeatedly in the mitochondrial genome of the demosponge Axinella corrugata and appears to be a common phenomenon in the evolution of the tRNA multigene family.