The procerebrum is necessary for odor-aversion learning in the terrestrial slug Limax valentianus
The procerebrum is necessary for odor-aversion learning in the terrestrial slug Limax valentianus
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DOI：
10.1101/lm.257606
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发表时间：
2006-07-01
影响因子：
2
通讯作者：
Matsuo, Ryota
中科院分区：
文献类型：
--
作者：
Kasai, Yoko;Watanabe, Satoshi;Matsuo, Ryota
陆栖鼻涕虫Limax具有高度发达的能力，可以将一些食物(如胡萝卜汁)的气味与令人厌恶的刺激联系起来，如奎尼丁溶液的苦味。前脑(PC)是鼻涕虫大脑的一部分，被认为与气味厌恶学习有关，但直接证据仍然缺乏。在这里，我们提出的证据表明，个人电脑对气味厌恶学习是必不可少的。与假手术的鼻涕虫不同，在条件化前7d的PC消融显示，在条件化后24小时进行的记忆保持测试中，大多数鼻涕虫不能避开胡萝卜汁。在条件作用后3h、1CL、3d或7d进行PC消融，并在PC消融后3d进行记忆保持测试的弹头也比假手术的弹头更不可能避免胡萝卜汁。PC消融术没有损害鼻涕虫感觉诱人气味(日常食物)或天生讨厌的气味(洋葱或大蒜)的能力。这些结果表明，在气味厌恶记忆的保持和/或提取过程中，PC是一个必要的组成部分。
The terrestrial slug Limax has a highly developed ability to associate the odor of some foods (e.g., carrot juice) with aversive stimuli such as the bitter taste of quinidine solution. The procerebrum (PC) is a part of the slug's brain thought to be involved in odor-aversion learning, but direct evidence is still lacking. Here we present evidence showing that the PC is essential for odor-aversion learning. Unlike sham-operated slugs, PC ablation 7 d prior to conditioning showed that most slugs did not avoid carrot juice in the memory retention test conducted 24 h after the conditioning. Slugs with the PC ablated 3 h, 1 cl, 3 d, or 7 d after conditioning and examined by the memory retention test at 3 d after the PC ablation were also less likely to avoid carrot juice than sham-operated slugs. The PC ablation did not damage the ability of the slugs to sense attractive odor (everyday food) or innately aversive odor (onion or garlic). These results demonstrate that the PC is a necessary component in the retention and/or retrieval of odor-aversion memory.