The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
复制标题
化学递质在神经元-胶质细胞相互作用和感觉神经节疼痛中的作用
DOI：
10.1016/j.neubiorev.2019.11.019
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发表时间：
2020
影响因子：
8.2
通讯作者：
Oshima Masamitsu
中科院分区：
文献类型：
--
作者：
Matsuka Yoshizo;Afroz Shaista;Dalanon Junhel C.;Iwasa Takuma;Waskitho Arief;Oshima Masamitsu
神经病理性疼痛(NP)是由于周围或中枢神经系统受损引起的。它会导致痛觉过敏和痛觉过敏。近年来，各种研究人员研究了神经免疫系统在引起持续性疼痛中的作用。感觉神经节中没有突触接触，这使得它们在与疼痛相关的信号传递方面具有独特之处。在感觉神经节中，由于损伤，神经节细胞产生的神经递质或炎性物质等调节物负责神经元之间的交叉兴奋和神经元-神经胶质细胞的相互作用，从而影响化学传递。这种化学传递被认为是神经病理性疼痛的慢性和持续性的主要原因。本文综述了感觉神经节内神经递质或细胞因子释放所产生的疼痛信号。具体的研究领域包括：1)感觉神经元胞体释放的神经递质在疼痛中的作用；2)神经元-神经胶质细胞的相互作用；3)细胞因子在神经调节和疼痛中的作用。
Neuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotransmitters or the other modulators such as inflammatory substances produced by the ganglion cells, because of an injury, are responsible for the cross-excitation between neurons and neuron-glial interaction, thus affecting chemical transmission. This chemical transmission is considered mainly responsible for the chronicity and the persistent nature of neuropathic pain. This review examines the pain signalling due to neurotransmitter or cytokine release within the sensory ganglia. The specific areas focused on include: 1) the role of neurotransmitters released from the somata of sensory neurons in pain, 2) neuron-glia interaction and 3) role of cytokines in neuromodulation and pain.