Theragnostic imaging for radiation oncology: dose-painting by numbers
Theragnostic imaging for radiation oncology: dose-painting by numbers
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DOI：
10.1016/s1470-2045(05)01737-7
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发表时间：
2005-02-01
期刊：
影响因子：
51.1
通讯作者：
Bentzen, SM
中科院分区：
文献类型：
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作者：
Bentzen, SM
放射肿瘤学的治疗诊断成像是利用分子和功能成像来规定放射治疗单独或与其他治疗方式结合在个体患者中的四维空间加时间的三维辐射分布。正电子发射断层扫描，单光子发射CT和磁共振波谱的几个新的成像目标允许微环境或细胞表型的变化，调制辐射的影响，以三维映射。数字剂量描绘是一种在四维空间中描述逆向计划调强放疗剂量分布的策略。这种方法将彻底改变放射治疗的处方和计划方式，至少在理论上，将改善局部肿瘤控制和对未受影响组织的副作用方面的治疗结果。
Theragnostic imaging for radiation oncology is the use of molecular and functional imaging to prescribe the distribution of radiation in four dimensions-the three dimensions of space plus time-of radiotherapy alone or combined with other treatment modalities in an individual patient. Several new imaging targets for positron-emission tomography, single-photon-emission CT, and magnetic resonance spectroscopy allow variations in microenvironmental or cellular phenotypes that modulate the effect of radiation to be mapped in three dimensions. Dose-painting by numbers is a strategy by which the dose distribution delivered by inverse planned intensity-modulated radiotherapy is prescribed in four dimensions. This approach will revolutionise the way that radiotherapy is prescribed and planned and, at least in theory, will improve the therapeutic outcome in terms of local tumour control and side-effects to unaffected tissue.