Effect of Metal Nanoparticles on Biofilm formation of Streptococcus mutans
Effect of Metal Nanoparticles on Biofilm formation of Streptococcus mutans
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DOI：
10.11344/nano.9.61
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
M. Hashimoto;Hirotomo Yanagiuchi;H. Kitagawa;S. Yamaguchi;Y. Honda;S. Imazato
中科院分区：
文献类型：
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作者：
M. Hashimoto;Hirotomo Yanagiuchi;H. Kitagawa;S. Yamaguchi;Y. Honda;S. Imazato
金属纳米颗粒（NP）有可能通过杀死细菌或防止牙菌斑形成来控制口腔环境中的感染。然而，人们对它们对口腔细菌的抗菌特性知之甚少。本研究的目的是评估金 (Au) 和银 (Ag) 纳米颗粒对变形链球菌的抗菌和生物膜抑制作用。测试了两种通过其核心金属表面和芳环部分之间的金属-碳σ键稳定的纳米粒子。本研究评估了具有相同表面化学性质但具有两种不同核心金属成分（金和银）的纳米粒子对抗菌活性的影响。两种NPs的抗菌活性均较弱。 AgNPs 对变形链球菌表现出生物膜抑制作用；然而，AuNPs 没有发现抑制作用。
Metal nanoparticles (NPs) have the potential for use in infection control in the oral environment by killing bacteria or preventing plaque formation. However, little is known about their antibacterial properties against oral bacteria. The purpose of this study was to evaluate the antibacterial and biofilm inhibitory effects of gold (Au) and silver (Ag) NPs against S. mutans. Two NPs stabilized by metal-carbon σ-bonds between their core metal surfaces and the aromatic ring moieties were tested. This study evaluated the effect of NPs with the same surface chemistry but with two different core metal compositions (Au and Ag) on antibacterial activity. The antibacterial activity of both NPs was relatively weak. AgNPs exhibited a biofilm inhibitory effect against S. mutans; however, no inhibitory effect was found in AuNPs.