Genetic Heterogeneity in Algerian Human Populations.
Genetic Heterogeneity in Algerian Human Populations.
复制标题
DOI：
10.1371/journal.pone.0138453
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Comas D
中科院分区：
文献类型：
--
作者：
Bekada A;Arauna LR;Deba T;Calafell F;Benhamamouch S;Comas D
北非人口的人口统计学历史的特点是混合和隔离的复杂过程，模拟了其目前的基因库。不同的遗传祖先组成部分与不同的起源（本土，欧洲，中东和撒哈拉以南）和遗传异质性在该地区已被描述。在这一复杂的遗传景观中，非洲最大的国家阿尔及利亚的覆盖率很低，大多数研究都使用了单一的阿尔及利亚样本。为了评估阿尔及利亚的遗传异质性，对几个柏柏尔语和阿拉伯语群体的Y染色体、线粒体DNA和常染色体全基因组标记进行了分析。我们的研究结果表明，在阿尔及利亚发现的遗传异质性与地理或语言学无关，挑战了柏柏尔人群体遗传隔离和阿拉伯群体开放基因流的想法。此外，我们还发现，流入北非的外部基因流更多地由女性携带，而北非本土成分在父系传播的基因组区域中更常见。我们的研究结果突出了不同的人口统计学历史揭示了不同的标记，并敦促谨慎时，从部分基因组信息或从单一样本作为代表的总人口的一个地区得出一般性的结论。
The demographic history of human populations in North Africa has been characterized by complex processes of admixture and isolation that have modeled its current gene pool. Diverse genetic ancestral components with different origins (autochthonous, European, Middle Eastern, and sub-Saharan) and genetic heterogeneity in the region have been described. In this complex genetic landscape, Algeria, the largest country in Africa, has been poorly covered, with most of the studies using a single Algerian sample. In order to evaluate the genetic heterogeneity of Algeria, Y-chromosome, mtDNA and autosomal genome-wide makers have been analyzed in several Berber- and Arab-speaking groups. Our results show that the genetic heterogeneity found in Algeria is not correlated with geography or linguistics, challenging the idea of Berber groups being genetically isolated and Arab groups open to gene flow. In addition, we have found that external sources of gene flow into North Africa have been carried more often by females than males, while the North African autochthonous component is more frequent in paternally transmitted genome regions. Our results highlight the different demographic history revealed by different markers and urge to be cautious when deriving general conclusions from partial genomic information or from single samples as representatives of the total population of a region.