Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease.
Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic disease.
复制标题
前哨淋巴结切除术在无淋巴转移性疾病证据的头颈癌患者中的价值。
DOI：
10.1016/s0385-8146(01)00107-9
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Werner
中科院分区：
文献类型：
--
作者：
A. Dünne;C. Külkens;A. Ramaswamy;B. Folz;D. Brandt;B. Lippert;T. Behr;R. Moll;J. Werner
只有少数通讯涉及前哨淋巴结（SN）活检的价值，头颈部鳞状细胞癌（HNSCC）。根据38例临床N 0-neck患者的研究结果，对HNSCC.Patients和Methods 38例未经治疗的临床N 0-neck患者进行了术中SN活检分期。在术中识别出最热的淋巴结（SN 1）和更少示踪剂积聚的淋巴结（SN 2，SN 3）后，患者接受不同类型的颈淋巴结清扫术（ND）治疗，根据原发肿瘤的位置和范围进行调整。术后的SN 1 - 3和整个ND标本的组织学结果进行了compared.ResultsThe颈部转移性疾病的阶段表现为无病SN 1在32例。5例患者术中发现SN 1有孤立性转移，1例患者术中发现SN 2有孤立性转移。结论术中SN活检对HNSCC隐匿性淋巴结转移的诊断有重要价值。如果将该方法用作术中分期程序以研究第一个引流示踪剂积聚淋巴结（SN 1 -3），则可能有助于限制同侧ND的范围。
ObjectiveOnly few communications deal with the value of sentinel node (SN) biopsy for head and neck squamous cell carcinoma (HNSCC). Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed.Patients and methodsThirty-eight previously untreated patients with clinically N0-neck were staged by intraoperative SN biopsy. After intraoperative identification of the hottest node (SN1) and further less tracer accumulating lymph nodes (SN2, SN3), patients were treated by different types of neck dissection (ND), adjusted to the location and extent of the primary tumour. Postoperatively the histologic results of the SN1–3and the entire ND specimen were compared.ResultsThe stage of cervical metastatic disease was demonstrated by a disease-free SN1in 32 patients. In five patients an isolated metastasis could be proven in the intraoperatively identified SN1, while in the remaining patient an isolated metastasis was found in the SN2.ConclusionIntraoperative SN biopsy seems to be valuable for the detection of occult lymph node metastases in HNSCC. This method might help to limit the extent of ipsilateral ND, if used as an intraoperative staging procedure to investigate the first draining tracer accumulating lymph nodes (SN1–3).