A Modeling Study on How Cell Division Affects Properties of Epithelial Tissues Under Isotropic Growth
A Modeling Study on How Cell Division Affects Properties of Epithelial Tissues Under Isotropic Growth
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DOI：
10.1371/journal.pone.0011750
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发表时间：
2010-07-30
期刊：
影响因子：
3.7
通讯作者：
Jonsson, Henrik
中科院分区：
文献类型：
--
作者：
Sahlin, Patrik;Jonsson, Henrik
细胞增殖影响生长组织中的细胞几何形状和拓扑结构，因此细胞分裂规则是理解多细胞发育的关键。长期以来，上皮细胞层一直用于研究细胞增殖如何导致组织规模的特性，包括细胞面积和相邻细胞数量的生物体独立分布。我们使用一个基于细胞的二维组织生长模型，包括力学研究不同的细胞分裂规则如何导致不同的统计特性的细胞在组织水平。我们专注于各向同性的生长和分裂的规则，建议植物细胞，并比较模型与数据从拟南芥芽。我们发现，几个划分规则可以导致正确的邻居数量的分布，在最近的研究中看到。此外，我们发现，当也考虑到几何特性的细胞分裂规则的结果的其他限制。我们发现，分裂规则有利于大小相等，形状对称的子细胞可以最好地描述统计组织特性。
Cell proliferation affects both cellular geometry and topology in a growing tissue, and hence rules for cell division are key to understanding multicellular development. Epithelial cell layers have for long times been used to investigate how cell proliferation leads to tissue-scale properties, including organism-independent distributions of cell areas and number of neighbors. We use a cell-based two-dimensional tissue growth model including mechanics to investigate how different cell division rules result in different statistical properties of the cells at the tissue level. We focus on isotropic growth and division rules suggested for plant cells, and compare the models with data from the Arabidopsis shoot. We find that several division rules can lead to the correct distribution of number of neighbors, as seen in recent studies. In addition we find that when also geometrical properties are taken into account other constraints on the cell division rules result. We find that division rules acting in favor of equally sized and symmetrically shaped daughter cells can best describe the statistical tissue properties.