Multi-modulation of nuclear receptor coactivators through posttranslational modifications.
Multi-modulation of nuclear receptor coactivators through posttranslational modifications.
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DOI：
10.1016/j.tem.2008.10.001
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发表时间：
2009-01
影响因子：
10.9
通讯作者：
O'Malley, Bert W.
中科院分区：
文献类型：
--
作者：
Han, Sang Jun;Lonard, David M.;O'Malley, Bert W.
核受体(NR)共激活子被核受体(NRS)招募到DNA上，增强核受体依赖的基因转录。为了在有限数量的辅助激活子的情况下获得NR介导的基因调控的复杂性，辅助激活子的分子性质被翻译后修饰(PTM)动态地调节以响应外界刺激。PTMS可以调节辅活化子与转录因子和其他辅活化子的分子相互作用，以及它们的细胞定位、蛋白质稳定性、构象和酶活性。因此，PTMS对辅活化子分子性质的动态调节使得NR依赖的基因表达变得复杂，并影响了NR介导的生理过程的调节。本文主要介绍了辅活化子PTM如何影响NR介导的基因转录及其生物学意义的最新进展。
Nuclear receptor (NR) coactivators are recruited to DNA by NRs, potentiating NR-dependent gene transcription. To obtain the complexity of NR-mediated gene regulation with a finite number of coactivators, the molecular properties of coactivators are dynamically modulated by posttranslational modifications (PTMs) in response to external stimuli. PTMs can regulate the molecular interactions of coactivators with transcription factors and other coactivators, as well as their cellular location, protein stability, conformation, and enzymatic activity. Therefore, dynamic regulation of the molecular properties of coactivators by PTMs allows for the complexity of NR-dependent gene expression and influences the regulation of NR-mediated physiological processes. This review focuses on recent progress in our understanding of how coactivator PTMs influence NR-mediated gene transcription and addresses their biological relevance.
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DOI：
10.1073/pnas.0610792104
发表时间：
2007-07-24
影响因子：
11.1
作者：
Higashimoto, Ken;Kuhn, Peter;Xu, Wei
通讯作者：
Xu, Wei
影响因子：
64.5
作者：
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通讯作者：
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DOI：
10.1073/pnas.0407159102
发表时间：
2005-03-08
影响因子：
11.1
作者：
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通讯作者：
Stallcup, MR
DOI：
10.1073/pnas.0705070104
发表时间：
2007-07-17
影响因子：
11.1
作者：
Jaeger, Sibylle;Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
5.3
作者：
Feng, Qin;Yi, Ping;O'Malley, Bert W.
通讯作者：
O'Malley, Bert W.