Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone
Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone
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DOI：
10.1161/hy0202.104272
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发表时间：
2002-02-01
期刊：
影响因子：
8.3
通讯作者：
Allen, AM
中科院分区：
文献类型：
--
作者：
Allen, AM
实验证据表明，下丘脑室旁核调节交感神经血管紧张度和血压，并且这种调节在某些心血管疾病中被改变。本研究验证了这一假设，即该核发挥了更显着的紧张性兴奋性调制的基础交感血管活性在自发性高血压大鼠。在麻醉、人工通气的大鼠中，向室旁核中双侧微量注射GABA（A）受体激动剂蝇蕈醇（每侧1 ~ 1.5纳摩尔），产生了一种抑制和交感神经抑制反应，这种反应不能恢复。与血压正常的大鼠相比，自发性高血压大鼠的这种反应更为明显，腰交感神经放电减少了75+/-3%，平均动脉压从119+/-7 mm Hg降至58+/-3 mm Hg。阻断延髓头端腹外侧区的兴奋性和抑制性氨基酸受体可显著减弱这种反应。微量注射小体积（
Experimental evidence indicates that the hypothalamic paraventricular nucleus modulates sympathetic vasomotor tone and blood pressure and that this modulation is altered in some cardiovascular diseases. This study tested the hypothesis that this nucleus exerts a more significant tonic excitatory modulation of basal sympathetic vasomotor activity in spontaneously hypertensive rats. In anesthetized, artificially-ventilated rats, bilateral microinjections of the GABA(A) receptor agonist, muscimol (1 to 1.5 nmoles per side), into the paraventricular nucleus produced a depressor and sympathoinhibitory response that did not recover. When compared with normotensive rats, this response was more marked in spontaneously hypertensive rats, where lumbar sympathetic nerve discharge was reduced by 75+/-3% and mean arterial pressure fell from 119+/-7 mm Hg to 58+/-3 mm Hg. Blockade of excitatory and inhibitory amino acid receptors in the rostral ventrolateral medulla significantly attenuated this response. Microinjections of small volumes (