NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria.
NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria.
复制标题
cd-H2O（一种来自白喉棒杆菌的 24 kDa 血红素加氧酶）的 NMR 归属。
DOI：
10.1007/s12104-007-9014-3
复制
发表时间：
2007
影响因子：
0.9
通讯作者：
Wilks,Angela
中科院分区：
文献类型：
--
作者：
Hom,Kellie;Furci,LenaM;Deshmukh,Rahul;Wilks,Angela
We are employing a number of selective in vitro and in vivo methods including NMR to screen compounds that bind to heme oxygenases from pathogenic bacteria. We report the nearly complete HN, N, CO, Cα and Cβ chemical shift assignments of a 215-amino acid HO fromCorynebacterium diphtheriain three forms, apocd-HO-G135A, apocd-HO and CO-bound ferrous holocd-HO; these assignments will enable us to identify residues oncd-HO that are perturbed upon binding to selected compounds, and to help with the development of inhibitors specific to the bacterial proteins.
