Brain pyruvate dehydrogenase: phosphorylation and enzyme activity altered by a training experience.
Brain pyruvate dehydrogenase: phosphorylation and enzyme activity altered by a training experience.
复制标题
脑丙酮酸脱氢酶：磷酸化和酶活性因训练经历而改变。
DOI：
10.1126/science.7291989
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Routtenberg,A
中科院分区：
文献类型：
--
作者：
Morgan,DG;Routtenberg,A
The active portion of the alpha subunit of pyruvate dehydrogenase in rat frontal cortex was elevated after a training experience. No change in total pyruvate dehydrogenase activity was observed. The phosphorylation in vitro of pyruvate dehydrogenase (band F-2) was also elevated after training. Since activation of pyruvate dehydrogenase requires its dephosphorylation, the following sequence is proposed. Training alters frontal cortex activity and reduces the phosphate content of pyruvate dehydrogenase in vivo; this leads to enzyme activation and an increase in back-titration of sites available for phosphorylation in vitro.
