How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?
How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?
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DOI：
10.1007/s00261-020-02496-5
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Leapman MS
中科院分区：
文献类型：
--
作者：
Rajwa P;Syed J;Leapman MS
回顾目前有关已知或疑似前列腺癌患者的非影像学生物标志物的证据。几种非成像生物标志物已经开发出来并可供使用，旨在改善几个关键临床时刻的风险评估。对于考虑首次或重复活检的怀疑患有前列腺癌的患者，基于血液和尿液的检测可以提高对具有临床意义的疾病的预测，并可能减少不必要的活检。基于血液和尿液的生物标志物已与前列腺 MRI 相关联进行了评估，提供了可能增强 MRI 前后决策的见解。还开发了基于组织的基因组和蛋白质组检测，可提供前列腺癌侵袭性的独立评估，从而补充成像。越来越多的非成像生物标志物可用于协助已知或疑似前列腺癌男性的临床决策。对成像和生物标志物交叉的认识可能会改善前列腺癌男性的临床护理和资源利用。
To review the current body of evidence surrounding non-imaging biomarkers in patients with known or suspected prostate cancer. Several non-imaging biomarkers have been developed and are available that aim to improve risk estimates at several critical clinical junctures. For patients with suspicion of prostate cancer considering first-time or repeat biopsy, blood and urine-based assays can improve the prediction of harboring clinically-significant disease and may reduce unnecessary biopsy. Blood and urine-based biomarkers have been evaluated in association with prostate MRI, offering insights that might augment decision-making in the pre and post-MRI setting. Tissue based genomic and proteomic assays have also been developed that provide independent assessments of prostate cancer aggressiveness that may complement imaging. A growing number of non-imaging biomarkers are available to assist in clinical decision-making for men with known or suspected prostate cancer. An appreciation for the intersection of imaging and biomarkers may improve clinical care and resource utilization for men with prostate cancer.
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