The moderate-intensity continuous exercise maintains renal blood flow and does not impair the renal function.
The moderate-intensity continuous exercise maintains renal blood flow and does not impair the renal function.
复制标题
DOI：
10.14814/phy2.15420
复制
发表时间：
2022-08
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
对于肾功能下降的人来说，运动是有限的，因为运动会减少流向肾脏的血液。对于肾功能减退的人来说，安全有效的锻炼计划尚未开发。我们之前研究了运动强度和肾血流量（RBF）之间的关系，揭示了中等强度的运动不会降低RBF。确定运动持续时间对RBF的影响可能具有重要的临床应用价值。目前的研究探讨了乳酸阈值（LT）强度的单次持续运动对肾脏血流动力学的影响。8名成年男性参与了这项研究。参与者进行了30分钟的有氧运动，在LT强度使用自行车测力计。在运动前和运动后，在恢复期使用超声回波进行肾血流动力学评价。此外，在运动前和运动后的恢复阶段进行血液和尿液采样。与静息时相比，持续运动后即刻RBF无显著变化（319 ± 102 vs. 308 ± 79 ml/min; p = 0.976），恢复期无显著变化。此外，尿肾损伤分子-1（uKIM-1）水平在连续运动后即刻无显著变化（0.52 ± 0.20 vs. 0.46 ± 0.27 μg/g肌酐; p = 0.447）。此外，结果显示，运动后60分钟内尿uKIM-1无显著变化。其他肾损伤生物标志物表现出类似的模式。这些发现表明，单次中等强度的持续运动可以维持RBF，不会引起肾损伤。
Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that moderate‐intensity exercise did not reduce RBF. Determining the effects of exercise duration on RBF may have valuable clinical applications. The current study examined the effects of a single bout of continuous exercise at lactate threshold (LT) intensity on renal hemodynamics. Eight adult males participated in this study. Participants underwent 30 min of aerobic exercise at LT intensity using a cycle ergometer. Evaluation of renal hemodynamics was performed before and after exercise, in the recovery phase using ultrasound echo. Furthermore, blood and urine samplings were conducted before and after exercise, in the recovery phase. Compared with resting, RBF was not significantly changed immediately after continuous exercise (319 ± 102 vs. 308 ± 79 ml/min; p = 0.976) and exhibited no significant changes in the recovery phase. Moreover, urinary kidney injury molecule‐1 (uKIM‐1) level exhibited no significant change immediately after continuous exercise (0.52 ± 0.20 vs. 0.46 ± 0.27 μg/g creatinine; p = 0.447). In addition, the results revealed no significant change in urinary uKIM‐1 in 60‐min after exercise. Other renal injury biomarkers exhibited a similar pattern. These findings indicate that a single bout of moderate‐intensity continuous exercise maintains RBF and does not induce renal injury.