Zosteriform metastatic skin cancer: Report of three cases and review of the literature
Zosteriform metastatic skin cancer: Report of three cases and review of the literature
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DOI：
10.1159/000051670
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发表时间：
2001-01-01
期刊：
影响因子：
3.4
通讯作者：
Nomura, K
中科院分区：
文献类型：
--
作者：
Kikuchi, Y;Matsuyama, A;Nomura, K
背景：转移性皮肤癌是一种罕见的并发症的内部恶性肿瘤。发生皮肤转移的患者很少出现带状疱疹样分布。目的：为探讨带状疱疹样转移性皮肤癌的特点，本文对15例文献报道的带状疱疹样转移性皮肤癌和3例临床诊断的带状疱疹样转移性皮肤癌进行了临床和组织病理学分析。研究方法：对18例带状疱疹样皮肤癌患者的年龄、性别、原发部位、原发灶和转移灶的病理、皮肤癌的部位和疼痛情况进行了测定。结果如下：原发肿瘤最常见的部位是乳腺（4例）、卵巢或肺（各3例）、前列腺、膀胱或胃（各2例）和子宫或结肠（各1例）。皮肤转移最常见的部位是胸壁（8例）和腹壁（7例）。原发灶组织学类型符合腺癌10例，移行细胞癌或浆液性乳头状囊腺癌各2例，导管癌1例。11例发生在与原发肿瘤最近的覆盖皮肤和/或同侧。11名患者抱怨疼痛。7例患者作为疱疹病毒试验者接受抗病毒药物治疗。结论：大约50%的转移性皮肤癌病例发生在最近的皮肤覆盖物上，并且与原发肿瘤在同一侧。当试图确定原发肿瘤的位置时，这些证据可能是有用的。三分之一的皮肤转移患者被误诊，他们的病灶最初被当作疱疹测试器治疗。当内部恶性肿瘤患者出现带状皮疹时，应考虑皮肤转移的可能性。皮肤活检是必要的，以确认诊断。版权所有（C）2001 S. Karger AG，巴塞尔。
Background: Metastatic skin cancer is a rare complication of internal malignancies. Patients who do develop skin metastases seldom present with a zosteriform distribution. Objective: To elucidate the characteristics of zosteriform metastatic skin cancer, 15 cases from the medical literature and 3 cases seen in our clinic were reviewed clinically and histopathologically. Methods: The age and sex of each patient, site of the primary tumor, pathology of primary and metastatic lesions, location of the skin cancer and presence of pain were determined for the 18 cases of zosteriform skin cancer. Results: The most frequent site of the primary tumor was the breast (4 cases), ovary or lung (3 cases each), prostate, bladder or stomach (2 cases each) and uterus or colon (1 case each). The most common site of the skin metastases was the chest wall (8 cases) and abdominal wall (7 cases). The histology of the primary lesion was compatible with adenocarcinoma (10 cases), transitional cell carcinoma or serous papillary cystadenocarcinoma (2 cases each) and ductal carcinoma (1 case). Eleven cases developed on the nearest covering skin and/or on the same side as the primary tumor. Eleven patients complained of pain. Seven cases were treated as herpes tester with antiviral agents. Conclusion: Approximately 50% of cases of metastatic skin cancer developed on the nearest skin covering and on the same side as the primary tumor. This evidence may be useful when trying to pinpoint the location of the primary tumor. One third of patients with skin metastases were misdiagnosed and their lesions were treated initially as herpes tester. When a band-like eruption is seen in patients with internal malignancies, the possibility of metastatic skin lesions should be considered. A skin biopsy is necessary to confirm the diagnosis. Copyright (C) 2001 S. Karger AG, Basel.