Non-adrenergic, non-cholinergic salivary secretion in the ferret.
Non-adrenergic, non-cholinergic salivary secretion in the ferret.
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雪貂的非肾上腺素能、非胆碱能唾液分泌。
DOI：
10.1113/expphysiol.1988.sp003129
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发表时间：
1988
影响因子：
--
通讯作者：
G. Tobin
中科院分区：
文献类型：
--
作者：
J. Ekström;B. Månsson;L. Olgart;G. Tobin
分泌腮腺和下颌下唾液诱发的副交感神经的电刺激发生在肾上腺素能和胆碱能阻断剂的存在下。与给予抗毒蕈碱剂前的反应相比，“阿托品抵抗”反应在下颌下腺中约为30%，在腮腺中约为5%。“抗阿托品”分泌频率较高，刺激开始和分泌开始之间的潜伏期较长。在长时间刺激后，“抗阿托品”分泌迅速而显著地减少。静脉注射速激肽P物质（SP）和K物质，引起唾液从两个腺体流出。单独给予外源性血管活性肠肽（VIP）不引起唾液流。然而，它增强速激肽诱发的分泌反应。在自主神经受体阻断剂的存在下，当静脉注射这种肽与神经刺激相结合时，对SP的反应也得到增强，即使是在分泌的阈下频率下。速激肽和VIP都是参与介导“抗阿托品”分泌反应的假定递质。
Secretion of parotid and submandibular saliva evoked by electrical stimulation of the parasympathetic nerves occurred in the presence of adrenergic and cholinergic blocking agents. The 'atropine-resistant' response amounted to about 30% in the submandibular gland and to about 5% in the parotid gland as compared to the response before administration of antimuscarinic agents. The 'atropine-resistant' secretion was found at relatively high frequencies, and the latency between the start of the stimulation and the onset of secretion was long. Upon long-lasting stimulation the 'atropine-resistant' secretion decreased rapidly and markedly. The tachykinins substance P (SP) and substance K, injected I.V., evoked flow of saliva from both glands. Given singly, exogenous vasoactive intestinal peptide (VIP) caused no salivary flow. However, it enhanced the tachykinin-evoked secretory response. The response to SP was also enhanced when I.V. injections of this peptide were combined with nerve stimulation, even at subthreshold frequencies for secretion, in the presence of the autonomic receptor blockers. Both tachykinins and VIP are putative transmitters involved in mediating the 'atropine-resistant' secretory response.