Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives
Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives
复制标题
DOI：
10.1007/s00044-010-9338-x
复制
发表时间：
2011-05
影响因子：
2.6
通讯作者：
M. Aytemi̇r;B. Özçelik
中科院分区：
文献类型：
--
作者：
M. Aytemi̇r;B. Özçelik
合成了一系列新型 6-氯甲基-3-羟基-2-取代的 4H-吡喃-4-酮衍生物，并测试了其体外抗菌、抗真菌和抗病毒特性。从活性结果来看，化合物8-11（MIC：8μg/ml）对金黄色葡萄球菌和粪肠球菌的活性更显着。化合物 1-7 对白色念珠菌和近平滑念珠菌具有高度活性，MIC 值为 8 μg/ml。带有3-氯苯基部分的化合物9被确定为针对RNA病毒PI-3最有活性的化合物。
A novel series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antibacterial, antifungal and antiviral in vitro properties. In the view of activity results, compounds8–11(MIC: 8 μg/ml) were more remarkably active againstStaphylococcus aureusandEnterococcus faecalis. Compounds1–7were highly active againstCandida albicansandC.parapsilosiswith MIC value of 8 μg/ml. Compound9bearing 3-chlorophenyl moiety was determined to be the most active compound against RNA virusPI-3.