RELATIONSHIP BETWEEN RISK-FACTORS FOR BREAST-CANCER AND HORMONAL STATUS
RELATIONSHIP BETWEEN RISK-FACTORS FOR BREAST-CANCER AND HORMONAL STATUS
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DOI：
10.1093/ije/15.4.469
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发表时间：
1986-12-01
影响因子：
7.7
通讯作者：
KAN, L
中科院分区：
文献类型：
--
作者：
HISLOP, TG;COLDMAN, AJ;KAN, L
共有 512 名乳腺癌患者和 540 名对照者进行了比较，以检查根据年龄、绝经状态和雌激素受体 (ER) 肿瘤状态定义的不同类别乳腺癌的危险因素。更年期状况、所有女性的首次生育年龄和初潮年龄、以及 45 至 54 岁之间女性的首次生育饲料和家族史均存在显着差异。仅 ER 状态没有发现显着差异；然而，绝经前女性的 ER 状态和体重之间存在显着差异；当按 ER 肿瘤状态分层时，未发现上述与绝经状态的显着差异。这些发现支持绝经前和绝经后乳腺癌病因学差异的假设，并表明 ER 肿瘤状态可能影响与体重相关的风险。
A total of 512 breast cancer patients and 540 controls were compared to examine the risk factors for different categories of breast cancer as defined by age, menopausal status and estrogen receptor (ER) tumor status. Significant differences were found by menopausal status, for age at first birth and age at menarche for all women, and forage at first birth and family history for women between 45 and 54 years old. No significant differences were found with ER status alone; however there was a significant difference between ER status and body weight in premenopausal women; the above significant differences with menopausal status were not found when stratified by ER tumour status. These findings support the hypothesis for aetiological differences for pre- and postmenopausal breast cancer and suggest that ER tumour status may influence the risk associated with body weight.