Multiple genes encoding pheromones and a pheromone receptor define the B beta 1 mating-type specificity in Schizophyllum commune.
Multiple genes encoding pheromones and a pheromone receptor define the B beta 1 mating-type specificity in Schizophyllum commune.
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发表时间：
1997-06
期刊：
影响因子：
3.3
通讯作者：
L. Vaillancourt;M. Raudaskoski;C. Specht;C. Raper
中科院分区：
文献类型：
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作者：
L. Vaillancourt;M. Raudaskoski;C. Specht;C. Raper
腐木蘑菇裂褶菌群中定义多种 B 交配类型的基因预计会编码多种信息素和信息素受体。这些基因聚集在两个可重组且独立功能的基因座 B α 和 B β 中的每一个中。一对交配个体之间任一基因座的特异性差异会引发性形态发生中一系列相同的事件。最近发现 B α 1 基因座包含预计编码三种脂肽信息素和具有七次跨膜结构域的信息素受体的基因。这些基因产物以异源特异性对（一种 B α 特异性的信息素与其他八种 B α 特异性中的任何一种的受体）相互作用，并且可能激活类似于酿酒酵母交配的信号级联。我们在此报告，B beta 1 基因座还包含至少三个信息素基因和一个信息素受体基因，其功能与 B α 1 基因座中的基因类似，但仅限于 B beta 特异性系列内。 B α 1 和 B β 1 基因座 DNA 序列的比较表明，每个基因座都源自共同的祖先序列，这使我们能够推测这一系列独特的调控基因的进化。
The genes defining multiple B mating types in the wood-rotting mushroom Schizophyllum commune are predicted to encode multiple pheromones and pheromone receptors. These genes are clustered in each of two recombinable and independently functioning loci, B alpha and B beta. A difference in specificity at either locus between a mated pair of individuals initiates an identical series of events in sexual morphogenesis. The B alpha 1 locus was recently found to contain genes predicted to encode three lipopeptide pheromones and a pheromone receptor with a seven-transmembrane domain. These gene products interact in hetero-specific pairs, the pheromone of one B alpha specificity with the receptor of any one of the other eight B alpha specificities, and are likely to activate a signaling cascade similar to that known for mating in Saccharomyces cerevisiae. We report here that the B beta 1 locus also contains at least three pheromone genes and one pheromone receptor gene, which function similarly to the genes in the B alpha 1 locus, but only within the series of B beta specificities. A comparison of the DNA sequences of the B alpha 1 and B beta 1 loci suggests that each arose from a common ancestral sequence, allowing us to speculate about the evolution of this unique series of regulatory genes.