Daughters and Mothers Against Breast Cancer (DAMES): main outcomes of a randomized controlled trial of weight loss in overweight mothers with breast cancer and their overweight daughters.
Daughters and Mothers Against Breast Cancer (DAMES): main outcomes of a randomized controlled trial of weight loss in overweight mothers with breast cancer and their overweight daughters.
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DOI：
10.1002/cncr.28761
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发表时间：
2014-08-15
期刊：
影响因子：
6.2
通讯作者：
Lipkus, Isaac M.
中科院分区：
文献类型：
--
作者：
Demark-Wahnefried, Wendy;Jones, Lee W.;Snyder, Denise C.;Sloane, Richard J.;Kimmick, Gretchen G.;Hughes, Daniel C.;Badr, Hoda J.;Miller, Paige E.;Burke, Lora E.;Lipkus, Isaac M.
到目前为止，很少有研究将癌症诊断作为一个可教育的时刻，以促进癌症幸存者及其家庭成员的健康行为改变。鉴于肥胖在乳腺癌一级和三级预防中的作用，作者探讨了母女减肥干预的可行性。在68对母女（n = 136）中进行了一项邮寄减肥干预的随机对照试验，每对母女包括一名乳腺癌幸存者（AJCC 0-III期）和她的成年亲生女儿。所有女性的体重指数均≥ 25 kg/m2，并在基线、6个月和12个月时进行了面对面评估，对一部分人进行了加速度计和运动能力评估。所有女性在一年内都收到了一本个性化的工作手册和6份时事通讯，这些通讯促进了减肥;运动;以及营养丰富，低能量密度的饮食。共有25对接受了单独定制的指导（个人），25对接受了团队定制的指导（团队），18对接受了标准化的小册子（对照）。该试验达到了其累积目标，经历了90%的保留，并没有引起严重的不良事件。个体母亲与对照母亲的体重指数、体重和腰围（WC）从基线到12个月的变化存在显著差异;相应女儿的WC也存在显著差异（P <0.05）。在WC（分别为P = 0.0002和0.018）、每周体力活动分钟数（分别为P = 0.031和0.036）和运动能力（均为P = 0.047）方面，个体与对照组以及团队与对照组之间存在显著差异。通过针对癌症幸存者及其家庭成员的定制印刷干预措施，生活方式行为和健康结果可能会得到显着改善。为了产生更大的影响，需要进行更多的研究，将这项工作扩展到母女二人组之外。Cancer 2014;120：2522-2534.© 2014作者。出版社：Wiley Periodicals，Inc.代表美国癌症协会肥胖是几种癌症发病率和死亡率的主要危险因素。这项在136名被诊断患有乳腺癌的妇女及其亲生女儿中进行的体重减轻随机对照试验的结果表明，癌症的诊断可以用来激励癌症幸存者及其家庭成员使用邮寄印刷干预措施的健康饮食和运动行为。
Few studies to date have used the cancer diagnosis as a teachable moment to promote healthy behavior changes in survivors of cancer and their family members. Given the role of obesity in the primary and tertiary prevention of breast cancer, the authors explored the feasibility of a mother-daughter weight loss intervention. A randomized controlled trial of a mailed weight loss intervention was undertaken among 68 mother-daughter dyads (n = 136), each comprised of a survivor of breast cancer (AJCC stage 0-III) and her adult biological daughter. All women had body mass indices ≥ 25 kg/m2 and underwent in-person assessments at baseline, 6 months, and 12 months, with accelerometry and exercise capacity performed on a subset of individuals. All women received a personalized workbook and 6 newsletters over a 1-year period that promoted weight loss; exercise; and a nutrient-rich, low-energy density diet. A total of 25 dyads received individually tailored instruction (INDIVIDUAL), 25 dyads received team-tailored instruction (TEAM), and 18 dyads received standardized brochures (CONTROL). The trial met its accrual target, experienced 90% retention, and caused no serious adverse events. Significant differences in baseline to 12-month changes were observed between INDIVIDUAL versus CONTROL mothers for body mass index, weight, and waist circumference (WC); significant differences also were observed in the WC of corresponding daughters (P < .05). Significant differences were found between INDIVIDUAL versus CONTROL and TEAM versus CONTROL dyads for WC (P = .0002 and .018, respectively), minutes per week of physical activity (P = .031 and .036, respectively), and exercise capacity (P = .047 for both). Significant improvements in lifestyle behaviors and health outcomes are possible with tailored print interventions directed toward survivors of cancer and their family members. For greater impact, more research is needed to expand this work beyond the mother-daughter dyad. Cancer 2014;120:2522–2534. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. Obesity is a major risk factor for the incidence and mortality of several cancers. The results of this randomized controlled trial of weight loss among 136 women diagnosed with breast cancer and their biological daughters suggests that the diagnosis of cancer can be used to motivate healthy diet and exercise behaviors among survivors of cancer and their family members using mailed print interventions.
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DOI：
10.1249/01.mss.0000048836.67270.1f
发表时间：
2003-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Ransdell, LB;Taylor, A;Shultz, B
通讯作者：
Shultz, B
影响因子：
3.8
作者：
Kim, Youngmee;Kashy, Deborah A.;Smith, Tenbroeck G.
通讯作者：
Smith, Tenbroeck G.
DOI：
10.1111/j.1552-6909.2009.01082.x
发表时间：
2010-01-01
影响因子：
1.8
作者：
Noone, Joanne;Young, Heather M.
通讯作者：
Young, Heather M.
影响因子：
3.6
作者：
Kim, Youngmee;Wellisch, David K.;Spillers, Rachel L.
通讯作者：
Spillers, Rachel L.
影响因子：
5.9
作者：
Nezu, AM;Nezu, CM;Houts, PS
通讯作者：
Houts, PS