The gastrin gene promoter is regulated by p73 isoforms in tumor cells.
The gastrin gene promoter is regulated by p73 isoforms in tumor cells.
复制标题
胃泌素基因启动子受肿瘤细胞中 p73 亚型的调节。
作者：
Tomkova,K;El-Rifai,W;Vilgelm,A;Kelly,MC;Wang,TC;Zaika,AI
P73是p53家族的新成员，是一种转录因子，在癌症研究中越来越被认为是肿瘤发生和化疗药物敏感性的重要参与者。尽管p53和p73在结构和功能上有很大的相似之处，但越来越多的证据表明，p53和p73可能对其转录靶点进行不同的调控。在这项研究中，我们研究了p73在调节胃泌素基因启动子中的作用。胃泌素是一种肽激素，是决定许多人类恶性肿瘤进展的重要因素。我们的研究结果表明p73可以与胃泌素启动子结合。这导致胃泌素mRNA的转录上调。我们还发现胃泌素和p73转录本的水平在原发性胃肿瘤中相关。综上所述，我们的研究结果证明了胃泌素基因转录调控的新机制，并支持p53和p73可能在肿瘤中具有不同生物学作用的概念。
p73, a new p53 family member, is a transcription factor that is increasingly recognized in cancer research as an important player in tumorigenesis as well as in chemotherapeutic drug sensitivity. Despite the substantial structural and functional similarities to p53, accumulating evidence suggests that p53 and p73 may differently regulate their transcriptional targets. In this study, we have investigated the role of p73 in regulation of the gastrin gene promoter. Gastrin is a peptide hormone and an important factor in determining the progression of a number of human malignancies. Our results show that p73 can bind to the gastrin promoter. This leads to transcriptional upregulation of gastrin mRNA. We also found that the levels of gastrin and p73 transcripts correlate in primary gastric tumors. Taken together, our results demonstrate a novel mechanism for regulation of gastrin gene transcription and support a concept that p53 and p73 may have different biological roles in tumors.