Orthostatic hypotension as a risk factor for stroke - The atherosclerosis risk in communities (ARIC) study, 1987-1996
Orthostatic hypotension as a risk factor for stroke - The atherosclerosis risk in communities (ARIC) study, 1987-1996
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DOI：
10.1161/01.str.31.10.2307
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发表时间：
2000-10-01
期刊：
影响因子：
8.3
通讯作者：
Jones, D
中科院分区：
文献类型：
--
作者：
Eigenbrodt, ML;Rose, KM;Jones, D
背景和目的：直立性低血压（OH）和卒中之间的关系在纵向研究中很少被研究。本研究的目的是确定在调整已知的卒中危险因素后，OH是否能预测中年两族人群的缺血性卒中。舒张期，收缩期和共识OH进行了评估的基线协会和预测stroke. Methods的能力，在11 707人从社区动脉粥样硬化风险（ARIC）队列谁是免费的中风和明显的心脏病在基线，考克斯比例风险分析模型之间的关联OH在基线和缺血性中风事件超过7.9年的后续行动。OH被定义为收缩压下降大于或等于20毫米汞柱（收缩OH），舒张压下降大于或等于10毫米汞柱（舒张OH），或下降（共识OH）时，一个人从仰卧位改变为站立position.Results-OH是缺血性中风的预测，即使调整了许多中风的危险因素（共识OH：风险比。2.0; 95% CI，1.2至3.2）。虽然与OH相关的基线特征根据OH的类型而变化，所有类型的OH有类似的中风风险。结论-OH是一个容易获得的测量，可能有助于确定中年人中风的风险。
Background and Purpose-The association between orthostatic hypotension (OH) and stroke has rarely been investigated in longitudinal studies. The purpose of the present study was to determine whether OH predicts ischemic stroke in a middle-aged, biethnic population after adjustment for known stroke risk factors. Diastolic, systolic, and consensus OH were evaluated for baseline associations and for the ability to predict stroke.Methods-In 11 707 persons from the Atherosclerosis Risk in Communities (ARIC) cohort who were free of stroke and overt heart disease at baseline, Cox proportional hazards analyses modeled the association between OH at baseline and incident ischemic stroke over 7.9 years of follow-up. OH was defined as a systolic blood pressure drop greater than or equal to 20 mm Hg (systolic OH), a diastolic blood pressure drop greater than or equal to 10 mm Hg (diastolic OH), or a drop in either (consensus OH) when a person changed from a supine to standing position.Results-OH was predictive of ischemic stroke, even after adjustment for numerous stroke risk factors (consensus OH: hazard ratio. 2.0; 95% CI, 1.2 to 3.2). While the baseline characteristics associated with OH varied depending on the type of OH, all types of OH had a similar risk of stroke.Conclusions-OH is an easily obtained measurement that may help to identify middle-aged persons at risk for stroke.