K(+)-induced vasodilation in the rat kidney is dependent on the endothelium and activation of K+ channels.
K(+)-induced vasodilation in the rat kidney is dependent on the endothelium and activation of K+ channels.
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K( ) 诱导的大鼠肾脏血管舒张依赖于内皮细胞和 K 通道的激活。
DOI：
10.1016/j.ejphar.2004.12.025
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Qiu,Yue
中科院分区：
文献类型：
--
作者：
Quilley,John;Qiu,Yue
细胞外K+增加可引起内皮非依赖性血管扩张，K+被认为是一种内皮衍生的超极化因子。然而，内皮细胞被赋予K+通道，这些通道也可能对增加的K+做出反应。在苯肾上腺素升高灌流压力的大鼠离体肾模型上，观察了20、40和60μ摩尔氯化钾的血管扩张作用。KCL产生剂量依赖性的血管扩张反应，这种反应几乎被去除内皮细胞所消除，这也取消了缓激肽的血管扩张作用，但不影响硝普钠的作用。环氧合酶、一氧化氮合酶和细胞色素P450的抑制不影响KCl2的血管扩张作用，而四乙基铵(TEA)抑制K+通道的作用。氯化钡可减弱氯化钾的血管扩张作用，而河豚毒素/阿帕明则无此作用。这些结果表明，KCl引起内皮依赖性血管扩张，这种作用不依赖于一氧化氮(NO)、前列腺素和细胞色素P450，但依赖于内皮K+通道的激活。
Increased extracellular K+is reported to cause endothelium-independent vasodilation and K+has been proposed as an endothelium-derived hyperpolarizing factor. However, the endothelium is endowed with K+channels that may also be responsive to increased K+. We examined the vasodilator effect of bolus administration of 20, 40 and 60 μmol KCl in the rat isolated kidney in which perfusion pressure was elevated with phenylephrine. KCl produced dose-dependent vasodilator responses that were virtually abolished by removal of the endothelium which also abolished the vasodilator effect of bradykinin without affecting that to nitroprusside. The vasodilator effect of KCl was unaffected by inhibition of cyclooxygenase, nitric oxide synthase or cytochrome P450 but reduced by inhibition of K+channels with tetraethylammonium (TEA). Barium chloride reduced the vasodilator effects of KCl but charybdotoxin/apamin was without effect. These results indicate that KCl results in endothelium-dependent vasodilation that is independent of nitric oxide (NO), prostaglandins and cytochrome P450 but dependent on activation of endothelial K+channels.
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影响因子：
5.5
作者：
EDWARDS, FR;HIRST, GDS;SILVERBERG, GD
通讯作者：
SILVERBERG, GD
糖尿病大鼠的肾血管反应和类二十烷酸释放。
DOI：
10.1152/ajprenal.1989.257.5.f762
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Sarubbi,D;McGiff,JC;Quilley,J
通讯作者：
Quilley,J
影响因子：
5
作者：
Harris, D;Martin, PEM;Randall, MD
通讯作者：
Randall, MD
内皮源性超极化因子和钾利用不同机制诱导人体皮下阻力动脉松弛
影响因子：
7.3
作者：
C. McIntyre;C H Buckley;G C Jones;T C Sandeep;R C Andrews;A. I. Elliott;G A Gray;B C Williams;J A McKnight;B R Walker;P. Hadoke
通讯作者：
P. Hadoke
由于钾电流，钾通道激活剂可增强钙流入内皮细胞
DOI：
10.1007/bf00178979
发表时间：
1990
期刊：
Naunyn-Schmiedeberg's Archives of Pharmacology
影响因子：
--
作者：
A. Lückhoff;R. Busse
通讯作者：
R. Busse