Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
Association of CYP1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status.
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DOI：
10.1111/jre.12658
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发表时间：
2019-10
影响因子：
3.5
通讯作者：
Xiane Wang;Wenjing Li;Wenli Song;L. Xu;Li Zhang;Xiang-hui Feng;R. Lu;H. Meng
中科院分区：
文献类型：
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作者：
Xiane Wang;Wenjing Li;Wenli Song;L. Xu;Li Zhang;Xiang-hui Feng;R. Lu;H. Meng
背景与目的CYP1A1 rs1048943基因多态性与牙周炎相关，但其与侵袭性牙周炎(AGP)的关系尚未得到研究。本研究旨在探讨泛发性侵袭性牙周炎(GAgP)与CYP1A1基因rs1048943变异的关系，并分析其与高脂血症的相互作用是否影响牙周状况。方法对224例GAgP患者和139例健康对照进行病例对照研究。记录探诊深度(PD)、附着丧失(AL)、出血指数(BI)等临床参数。测定血小板计数(PLT)、血小板分布宽度(PDW)、血小板大细胞比率(PLCR)、平均血小板体积(MPV)、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)。用飞行时间质谱仪对CYP1A1 rs1048943单核苷酸多态进行基因分型。采用Logistic回归模型和线性回归模型进行相关性检验。结果调整协变量后，CYP1A1 rs1048943 AG/GG基因型与GAgP(OR=1.56，95%CI：1.01，2.42)、PD、AL及PDW、PLCR、MPV降低相关。在GAgP患者中，在PD(P交互作用=0.0033)、BI(P交互作用=0.0311)和AL(P交互作用=0.0141)和低密度脂蛋白(P交互作用=0.013)之间存在基因-脂质交互作用。结论CYP1A1rs1048943基因G等位基因与中国人群GAgP、牙周状态和血小板相关炎症状态相关。高脂血症可调节CYP1A1基因rs1048943对GAgP牙周状态的影响。
BACKGROUND AND OBJECTIVE CYP1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP1A1 gene rs1048943 variant with generalized aggressive periodontitis (GAgP) and platelet activation and analyse whether its interaction with hyperlipidemia affects periodontal status in a Chinese population. METHODS A case-control study of 224 GAgP patients and 139 healthy controls was conducted. The clinical parameters of probing depth (PD), attachment loss (AL) and bleeding index (BI) were recorded. Platelet count (PLT), platelet distribution width (PDW), platelet large cell ratio (PLCR), mean platelet volume (MPV), serum total cholesterol (TC), triacylglycerol (TG), high and low-density lipoprotein (HDL and LDL) were also measured. The CYP1A1 rs1048943 SNP was genotyped by time-of-flight mass spectrometry. Logistic and linear regression models were used to measure correlation. RESULTS The CYP1A1 rs1048943 AG/GG genotype was associated with GAgP (OR = 1.56, 95%CI: 1.01, 2.42), PD, AL and decreased PDW, PLCR and MPV after adjustment for covariates. Gene-lipid interactions were found between CYP1A1 rs1048943 and HDL for PD (Pinteraction = 0.0033), BI (Pinteraction = 0.0311) and AL (Pinteraction = 0.0141) and between CYP1A1 rs1048943 and LDL for PD (Pinteraction = 0.013) among patients with GAgP. CONCLUSION The G allele of the CYP1A1 rs1048943 gene was associated with GAgP, periodontal status and platelet-related inflammation status in a Chinese population. Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP.