A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement
A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement
复制标题
DOI：
10.1155/2017/7460780
复制
发表时间：
2017-01-01
影响因子：
4.6
通讯作者：
Torres-Lagares, D.
中科院分区：
文献类型：
--
作者：
Diaz Sanchez, R. M.;Castillo-Dali, G.;Torres-Lagares, D.
瞄准评价由低聚原花青素制成的新型营养补充剂在使用21天后对诱导性牙龈炎的组织反应的有效性。材料和方法。对20例患者进行前瞻性、双盲、随机、对照临床试验，符合入选标准后分为实验组和对照组。患者在研究期间必须来4次，以记录Silness和Loe指数、牙龈出血指数、牙菌斑指数、炎性龈沟液研究（IL 6）和牙龈亮度的变化。在这21天里，不允许使用补充卫生方法。结果对照组的Silness和Loe指数高于实验组，组间差异达2倍（p <0.0001）。牙龈出血指数也支持这一事实，因为实验组的出血量较低（P <0.005）。实验组牙面菌斑指数比对照组高33%（P <0.006）。龈沟液中IL-6含量存在一定差异（p <0.0001）。结论低聚原花青素对牙周组织的健康有影响。没有发现对牙菌斑在牙齿表面的积累有影响，因此需要进一步的研究来确定牙菌斑的性质。
Aim. To evaluate the effectiveness on tissue response of the new nutritional supplement made of oligomeric proanthocyanidins in induced gingivitis after 21 days of use. Material and Methods. A prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. Patients had to come 4 times during the study to register the Silness and Loe index, the gingival bleeding index, the plaque index, the inflammatory crevicular fluid study (IL6), and the changes in the brightness of the gingiva. No complementary hygiene methods were allowed during the 21 days. Results. The Silness and Loe index was higher in the control group than in the experimental group, reaching a twofold difference between the groups (p < 0 0001). The gingival bleeding index also supports this fact, since the bleeding was lower in the experimental group (p < 0 005). However, the dental plaque on the tooth surface according to the plaque index was 33% higher in the experimental group (p < 0 006). Some differences in the IL-6 were found in the crevicular fluid (p < 0 0001). Conclusion. Oligomeric proanthocyanidins have an effect on the periodontal tissue's health. No effects on the accumulation of plaque on the tooth surface were found, so further studies are needed to determine the nature of the plaque.