Cognitive function in congenital adrenal hyperplasia
Cognitive function in congenital adrenal hyperplasia
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DOI：
10.1016/s0889-8529(08)70025-2
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发表时间：
2001-03-01
影响因子：
4.5
通讯作者：
Berenbaum, SA
中科院分区：
文献类型：
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作者：
Berenbaum, SA
先天性肾上腺增生症（CAH）患者的认知能力受到有益和有害的影响，尽管这些患者的认知变化不像其他行为变化那样得到很好的记录。盐耗型（SW）和单纯性男性化（SV） CAH患者至少具有平均智力，尽管SW- CAH患者的智商可能略低于SV-CAH患者。患有CAH的患者似乎没有特别的学习障碍风险，但这个问题需要进一步研究，因为他们可能有特殊的学习问题的可能性。患有CAH的女孩和女性似乎由于在发育早期暴露于高水平的雄激素而具有增强的空间能力，并且有趣的正在进行的研究涉及这种优势的神经基质，以及雄激素是否也影响其他能力。越来越多的人关注，但很少有研究表明，CAH患者可能由于疾病特征（如盐丢失和低血糖事件）和疾病治疗（特别是糖皮质激素过量）而发生其他认知变化，这些变化反映在大脑变化（包括白质异常）中。
Cognition is affected in beneficial and harmful ways in patients with congenital adrenal hyperplasia (CAH), although cognitive changes are not as well documented as other behavioral changes in these patients. Patients with salt-wasting (SW) and simple virilizing (SV) CAH have at least average intelligence, although IQ may be somewhat lower in SW- than SV-CAH patients. Patients with CAH do not seem to be at special risk for learning disabilities, but this issue requires further study, as does the possibility that they may be likely to have specific learning problems. Girls and women with CAH seem to have enhanced spatial ability as a result of exposure to high levels of androgens early in development, and interesting ongoing studies are concerned with the neural substrate of this advantage, and whether androgen also affects other abilities. There is increasing concern, but little study, of the possibility that patients with CAH may have other cognitive changes as a consequence of disease characteristics, such as salt-losing and hypoglycemic events, and of the treatment of the disease, especially glucocorticoid excess, and that these are reflected in brain changes (including white-matter abnormalities).