Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
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DOI：
10.1016/j.atherosclerosis.2008.04.044
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发表时间：
2009-01-01
期刊：
影响因子：
5.3
通讯作者：
Kashyap, Moti L.
中科院分区：
文献类型：
--
作者：
Ganji, Shobha H.;Qin, Shucun;Kashyap, Moti L.
在药理学上，烟酸（烟酸）可减少心肌梗塞。中风和动脉粥样硬化。烟酸对脂蛋白的有益作用被认为可以介导这些作用。我们假设烟酸抑制氧化应激和氧化还原敏感炎症基因，这些基因在早期动脉粥样硬化形成中发挥关键作用。在培养的人主动脉内皮细胞 (HAEC) 中。烟酸使烟酰胺腺嘌呤二核苷酸磷酸 (NAD(P)H) 水平增加 54%，并使谷胱甘肽 (GSH) 水平减少 98%。烟酸抑制：(a) 血管紧张素 II (ANG II) 诱导的活性氧 (ROS) 产生 24-86%。 (b) 低密度脂蛋白(LDL)氧化60%。 (C)肿瘤坏死因子α(TNF-α)诱导NF-κB激活46％，血管细胞粘附分子-1(VCAM-1)诱导77-93％。单核细胞趋化蛋白-1 (MCP-1) 分泌增加 34-124%，(d) 在功能测定中 TNF-α 诱导的单核细胞粘附到 HAEC (41-54%)。这些发现首次表明，烟酸通过减少内皮活性氧的产生以及随后的低密度脂蛋白氧化和炎症细胞因子的产生（参与动脉粥样硬化形成的关键事件）来抑制血管炎症。本文提供的初始数据支持烟酸具有血管抗炎和潜在的抗动脉粥样硬化特性的新概念，与其对油脂调节的影响无关。由爱思唯尔爱尔兰有限公司出版
In pharmacological closes, nicotinic acid (niacin) reduces myocardial infarction. stroke and atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these effects. We hypothesized that niacin inhibits oxidative stress and redox-sensitive inflammatory genes that play a critical role in early atherogenesis. In Cultured human aortic endothelial cells (HAEC). niacin increased nicotinamide adenine dinucleotide phosphate (NAD(P)H) levels by 54% and reduced glutathione (GSH) by 98%. Niacin inhibited: (a) angiotensin II (ANG II)-induced reactive oxygen species (ROS) production by 24-86%. ( b) low density lipoprotein (LDL) oxidation by 60%. (C) tumor necrosis factor alpha (TNF-alpha)-induced NF-kappa B activation by 46%, vascular cell adhesion molecule-1 (VCAM-1) by 77-93%. monocyte chemotactic protein-1 (MCP-1) secretion by 34-124% and (d) in a functional assay TNF-alpha-induced monocyte adhesion to HAEC (41-54%). These findings indicate for the first time that niacin inhibits vascular inflammation by decreasing endothelial ROS production and subsequent LDL oxidation and inflammatory cytokine production, key events involved in atherogenesis. Initial data presented herein Support the novel concept that niacin has vascular anti-inflammatory and potentially anti-atherosclerotic properties independent of its effects oil lipid regulation. Published by Elsevier Ireland Ltd.