Family history as a risk factor for ulcerative colitis-associated colon cancer in cotton-top tamarin
Family history as a risk factor for ulcerative colitis-associated colon cancer in cotton-top tamarin
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DOI：
10.1016/s0016-5085(98)70580-3
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发表时间：
1998-04-01
期刊：
影响因子：
29.4
通讯作者：
Johnson, LD
中科院分区：
文献类型：
--
作者：
Bertone, ER;Giovannucci, EL;Johnson, LD
背景和目标：结肠癌家族史与溃疡性结肠炎相关性结肠癌的关系目前尚不清楚，本研究采用巢式病例对照研究方法，探讨了结肠癌家族史与棉顶绢毛猴自发性结肠癌的关系。研究方法：受试者从1968年至1995年期间圈养的棉顶绢毛猴群体中选择，比较了48只结肠癌动物和58只对照动物的父母和祖父母的癌症状况，所有动物均经组织学证实为溃疡性结肠炎。采用逻辑回归分析计算多变量比值比。结果如下：父母有结肠癌病史与结肠癌风险呈正相关（多变量优势比，2.7; 95%置信区间，1.1-6.3），风险也随着动物的结肠癌家族成员总数的增加而增加（多变量优势比，癌症家族成员总数每增加1.7; 95%置信区间，1.1-2.8）。结论：研究结果表明，患有溃疡性结肠炎的棉顶绢毛猴如果有结肠癌家族史，患结肠癌的风险会显著增加。在绢毛猴和人类中进一步研究这种关系是必要的。
Background & Aims: Little is currently known about the relationship between family history of colon cancer and ulcerative colitis-associated colon cancer, A nested case-control study was performed to evaluate the association between family history of colon cancer and spontaneously occurring colon cancer in cotton-top tamarins (Saguinus oedipus). Methods: Subjects were chosen from a colony of cotton-top tamarins held in captivity between 1968 and 1995, The cancer status of parents and grandparents was compared for 48 animals with colon cancer and 58 controls, all with histological confirmation of ulcerative colitis. Multivariate odds ratios were calculated using logistic regression. Results: A parental history of colon cancer was positively associated with risk of colon cancer (multivariate odds ratio, 2.7; 95% confidence interval, 1.1-6.3), Risk also increased as an animal's total number of family members with colon cancer increased (multivariate odds ratio, 1.7 for each increase in the total number of family members with cancer; 95% confidence interval, 1.1-2.8). Conclusions: The results suggest that cotton-top tamarins with ulcerative colitis are at significant increased risk for developing colon cancer if they have a family history of colon cancer. Further investigation of this relationship in both tamarins and humans is warranted.