Hyperbranched Polyelectrolyte Copolymers as Novel Candidate Delivery Systems for Bio-Relevant Compounds.
Hyperbranched Polyelectrolyte Copolymers as Novel Candidate Delivery Systems for Bio-Relevant Compounds.
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DOI：
10.3390/ma16031045
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发表时间：
2023-01-24
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影响因子：
--
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中科院分区：
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本研究利用可逆加成-断裂链转移（RAFT）聚合结合选择性水解反应合成了新型超支化聚（低聚乙二醇）甲基醚甲基丙烯酸酯-co-叔丁基甲基丙烯酸酯-co-甲基丙烯酸）（H-[P（OEGMA-co-tBMA-co-MAA）]）共聚物。通过尺寸排阻色谱（SEC）和1H-NMR光谱等物理化学技术对共聚物进行了表征。研究了超支化共聚物在水溶液中自组装成纳米结构的能力。动态光散射和荧光光谱显示多分子聚集体的纳米尺度的低临界聚集浓度，其大小和质量取决于共聚物的组合物和溶液条件，而zeta电位测量表明pH敏感的功能。此外，为了评估其作为纳米载体的潜在用途，分别利用姜黄素和溶菌酶作为模型疏水性药物和模型阳离子蛋白质，研究了共聚物的药物包封和蛋白质络合能力。
In this study, reversible addition-fragmentation chain transfer (RAFT) polymerization is utilized in order to synthesize novel hyperbranched poly(oligoethylene glycol) methyl ether methacrylate-co-tert-butyl methacrylate-co-methacrylic acid) (H-[P(OEGMA-co-tBMA-co-MAA)]) copolymers in combination with selective hydrolysis reactions. The copolymers showing amphiphilicity induced by the polar OEGMA and hydrophobic tBMA monomeric units, and polyelectrolyte character due to MAA units, combined with unique macromolecular architecture were characterized by physicochemical techniques, such as size exclusion chromatography (SEC) and 1H-NMR spectroscopy. The hyperbranched copolymers were investigated in terms of their ability to self-assemble into nanostructures when dissolved in aqueous media. Dynamic light scattering and fluorescence spectroscopy revealed multimolecular aggregates of nanoscale dimensions with low critical aggregation concentration, the size and mass of which depend on copolymer composition and solution conditions, whereas zeta potential measurements indicated pH sensitive features. In addition, aiming to evaluate their potential use as nanocarriers, the copolymers were studied in terms of their drug encapsulation and protein complexation ability utilizing curcumin and lysozyme, as a model hydrophobic drug and a model cationic protein, respectively.
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影响因子：
4.9
作者：
Chen, Liyu;Simpson, Joshua D.;Thurecht, Kristofer J.
通讯作者：
Thurecht, Kristofer J.
影响因子：
--
作者：
Luzon, Mario;Boyer, Cyrille;Davis, Thomas P.
通讯作者：
Davis, Thomas P.
影响因子：
6.1
作者：
Kumaraswamy, Priyadharshini;Sethuraman, Swaminathan;Krishnan, Uma Maheswari
通讯作者：
Krishnan, Uma Maheswari
影响因子：
4.1
作者：
Hong, Chi Rac;Park, Sung Joon;Choi, Seung Jun
通讯作者：
Choi, Seung Jun
影响因子：
4.2
作者：
Carr, Daniel A.;Gomez-Burgaz, Marta;Boudes, Mathilde C.;Peppas, Nicholas A.
通讯作者：
Peppas, Nicholas A.